TY  - JOUR
AU  - Tsunekawa, Taku
AU  - Banno, Ryoichi
AU  - Yaginuma, Hiroshi
AU  - Taki, Keigo
AU  - Mizoguchi, Akira
AU  - Sugiyama, Mariko
AU  - Onoue, Takeshi
AU  - Takagi, Hiroshi
AU  - Hagiwara, Daisuke
AU  - Ito, Yoshihiro
AU  - Iwama, Shintaro
AU  - Goto, Motomitsu
AU  - Suga, Hidetaka
AU  - Bettler, Bernhard
AU  - Arima, Hiroshi
TI  - GABAB Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet.
JO  - iScience
VL  - 20
SN  - 2589-0042
CY  - St. Louis
PB  - Elsevier
M1  - DKFZ-2019-02460
SP  - 337 - 347
PY  - 2019
AB  - Binge eating could contribute to the development of obesity, and previous studies suggest that gamma-aminobutyric acid (GABA) type B receptor (GABABR) signaling is involved in the regulation of binge eating. Here, we show that time-restricted access to a high-fat diet (HFD) induces binge-like eating behavior in wild-type mice. HFD consumption during restricted time was significantly increased in corticostriatal neuron-specific GABABR-deficient mice compared with wild-type mice. Furthermore, the GABABR agonist baclofen suppressed HFD intake during restricted time in wild-type mice but not in corticostriatal or dopaminergic neuron-specific GABABR-deficient mice. In contrast, there were no significant differences in food consumption among genotypes under ad libitum access to HFD. Thus, our data show that the mesolimbic system regulates food consumption under time-restricted but not ad libitum access to HFD and have identified a mechanism by which GABABR signaling suppresses binge-like eating of HFD.
LB  - PUB:(DE-HGF)16
C6  - pmid:31610370
DO  - DOI:10.1016/j.isci.2019.09.032
UR  - https://inrepo02.dkfz.de/record/147339
ER  -