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@ARTICLE{Tsunekawa:147339,
      author       = {T. Tsunekawa and R. Banno and H. Yaginuma and K. Taki and
                      A. Mizoguchi and M. Sugiyama and T. Onoue and H. Takagi and
                      D. Hagiwara$^*$ and Y. Ito and S. Iwama and M. Goto and H.
                      Suga and B. Bettler and H. Arima},
      title        = {{GABAB} {R}eceptor {S}ignaling in the {M}esolimbic {S}ystem
                      {S}uppresses {B}inge-like {C}onsumption of a {H}igh-{F}at
                      {D}iet.},
      journal      = {iScience},
      volume       = {20},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2019-02460},
      pages        = {337 - 347},
      year         = {2019},
      abstract     = {Binge eating could contribute to the development of
                      obesity, and previous studies suggest
                      that gamma-aminobutyric acid (GABA) type B receptor
                      (GABABR) signaling is involved in the regulation of binge
                      eating. Here, we show that time-restricted access to a
                      high-fat diet (HFD) induces binge-like eating behavior in
                      wild-type mice. HFD consumption during restricted time was
                      significantly increased in corticostriatal neuron-specific
                      GABABR-deficient mice compared with wild-type mice.
                      Furthermore, the GABABR agonist baclofen suppressed HFD
                      intake during restricted time in wild-type mice but not in
                      corticostriatal or dopaminergic neuron-specific
                      GABABR-deficient mice. In contrast, there were no
                      significant differences in food consumption among genotypes
                      under ad libitum access to HFD. Thus, our data show that the
                      mesolimbic system regulates food consumption under
                      time-restricted but not ad libitum access to HFD and have
                      identified a mechanism by which GABABR signaling suppresses
                      binge-like eating of HFD.},
      cin          = {V078},
      ddc          = {050},
      cid          = {I:(DE-He78)V078-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31610370},
      doi          = {10.1016/j.isci.2019.09.032},
      url          = {https://inrepo02.dkfz.de/record/147339},
}