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000147344 0247_ $$2doi$$a10.1016/j.jalz.2019.08.189
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000147344 1001_ $$0P:(DE-HGF)0$$aStocker, Hannah$$b0$$eFirst author
000147344 245__ $$aPrediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors
000147344 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2020
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000147344 500__ $$a2020 Feb;16(2):283-291#EA:C070#LA:C070#
000147344 520__ $$aAlzheimer's disease (AD) has a long prodromal stage and identifying high-risk individuals is critical. We aimed to investigate the ability of Aβ misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD.Within a community-based cohort, Aβ misfolding in plasma measured by immuno-infrared sensor and APOE genotype were determined at baseline in 770 participants followed over 14 years. Associations between Aβ misfolding, APOE4, and other predictors with clinical AD, vascular dementia, and mixed dementia diagnoses were assessed.Aβ misfolding was associated with a 23-fold increased odds of clinical AD diagnosis within 14 years. No association was observed with vascular dementia/mixed dementia diagnoses. APOE4-positive participants had a 2.4-fold increased odds of clinical AD diagnosis within 14 years.Aβ misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD even many years before diagnosis in a community-based setting.
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000147344 7001_ $$aNabers, Andreas$$b1
000147344 7001_ $$0P:(DE-He78)d9d72431035d8535d1b65ce9a01c2f60$$aPerna, Laura$$b2$$udkfz
000147344 7001_ $$0P:(DE-He78)6cc3cc35505b446fde081e7cd89a4b87$$aMöllers, Tobias$$b3$$udkfz
000147344 7001_ $$aRujescu, Dan$$b4
000147344 7001_ $$aHartmann, Annette$$b5
000147344 7001_ $$aHolleczek, Bernd$$b6
000147344 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b7$$udkfz
000147344 7001_ $$aGerwert, Klaus$$b8
000147344 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b9$$eLast author$$udkfz
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