TY  - JOUR
AU  - Stocker, Hannah
AU  - Nabers, Andreas
AU  - Perna, Laura
AU  - Möllers, Tobias
AU  - Rujescu, Dan
AU  - Hartmann, Annette
AU  - Holleczek, Bernd
AU  - Schöttker, Ben
AU  - Gerwert, Klaus
AU  - Brenner, Hermann
TI  - Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors
JO  - Alzheimer's and dementia
VL  - 16
IS  - 2
SN  - 1552-5260
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2019-02465
SP  - 283-291
PY  - 2020
N1  - 2020 Feb;16(2):283-291#EA:C070#LA:C070#
AB  - Alzheimer's disease (AD) has a long prodromal stage and identifying high-risk individuals is critical. We aimed to investigate the ability of Aβ misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD.Within a community-based cohort, Aβ misfolding in plasma measured by immuno-infrared sensor and APOE genotype were determined at baseline in 770 participants followed over 14 years. Associations between Aβ misfolding, APOE4, and other predictors with clinical AD, vascular dementia, and mixed dementia diagnoses were assessed.Aβ misfolding was associated with a 23-fold increased odds of clinical AD diagnosis within 14 years. No association was observed with vascular dementia/mixed dementia diagnoses. APOE4-positive participants had a 2.4-fold increased odds of clinical AD diagnosis within 14 years.Aβ misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD even many years before diagnosis in a community-based setting.
LB  - PUB:(DE-HGF)16
C6  - pmid:31611055
DO  - DOI:10.1016/j.jalz.2019.08.189
UR  - https://inrepo02.dkfz.de/record/147344
ER  -