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@ARTICLE{Stocker:147344,
      author       = {H. Stocker$^*$ and A. Nabers and L. Perna$^*$ and T.
                      Möllers$^*$ and D. Rujescu and A. Hartmann and B. Holleczek
                      and B. Schöttker$^*$ and K. Gerwert and H. Brenner$^*$},
      title        = {{P}rediction of {A}lzheimer's disease diagnosis within 14
                      years through {A}β misfolding in blood plasma compared to
                      {APOE}4 status, and other risk factors},
      journal      = {Alzheimer's and dementia},
      volume       = {16},
      number       = {2},
      issn         = {1552-5260},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2019-02465},
      pages        = {283-291},
      year         = {2020},
      note         = {2020 Feb;16(2):283-291#EA:C070#LA:C070#},
      abstract     = {Alzheimer's disease (AD) has a long prodromal stage and
                      identifying high-risk individuals is critical. We aimed to
                      investigate the ability of Aβ misfolding in blood plasma,
                      APOE4 status, and dementia risk factors to predict diagnosis
                      of AD.Within a community-based cohort, Aβ misfolding in
                      plasma measured by immuno-infrared sensor and APOE genotype
                      were determined at baseline in 770 participants followed
                      over 14 years. Associations between Aβ misfolding, APOE4,
                      and other predictors with clinical AD, vascular dementia,
                      and mixed dementia diagnoses were assessed.Aβ misfolding
                      was associated with a 23-fold increased odds of clinical AD
                      diagnosis within 14 years. No association was observed with
                      vascular dementia/mixed dementia diagnoses. APOE4-positive
                      participants had a 2.4-fold increased odds of clinical AD
                      diagnosis within 14 years.Aβ misfolding in blood plasma
                      was a strong, specific risk prediction marker for clinical
                      AD even many years before diagnosis in a community-based
                      setting.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31611055},
      doi          = {10.1016/j.jalz.2019.08.189},
      url          = {https://inrepo02.dkfz.de/record/147344},
}