%0 Journal Article
%A Schöttker, Ben
%A Xuan, Yang
%A Gào, Xīn
%A Anusruti, Ankita
%A Brenner, Hermann
%T Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study.
%J Diabetes care
%V 43
%N 1
%@ 1935-5548
%C Alexandria, Va.
%I Assoc.
%M DKFZ-2019-02504
%P 130-136
%D 2020
%Z 2020 Jan;43(1):130-136#EA:C070#LA:C070#
%X Oxidative stress is believed to play an important role in the pathophysiology of type 2 diabetes, but the few cohort studies that have assessed the association of oxidative stress biomarkers with type 2 diabetes incidence were small and reported inconclusive results.We examined the associations of urinary oxidized guanine/guanosine (OxGua) levels (a biomarker of DNA/RNA oxidation) and urinary 8-isoprostane levels (a biomarker of lipid peroxidation) with type 2 diabetes incidence in 7,828 individuals initially without diabetes from a population-based German cohort study with 14 years of follow-up. Hazard ratios (HRs) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31653645
%R 10.2337/dc19-1379
%U https://inrepo02.dkfz.de/record/147387