TY  - JOUR
AU  - Schöttker, Ben
AU  - Xuan, Yang
AU  - Gào, Xīn
AU  - Anusruti, Ankita
AU  - Brenner, Hermann
TI  - Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study.
JO  - Diabetes care
VL  - 43
IS  - 1
SN  - 1935-5548
CY  - Alexandria, Va.
PB  - Assoc.
M1  - DKFZ-2019-02504
SP  - 130-136
PY  - 2020
N1  - 2020 Jan;43(1):130-136#EA:C070#LA:C070#
AB  - Oxidative stress is believed to play an important role in the pathophysiology of type 2 diabetes, but the few cohort studies that have assessed the association of oxidative stress biomarkers with type 2 diabetes incidence were small and reported inconclusive results.We examined the associations of urinary oxidized guanine/guanosine (OxGua) levels (a biomarker of DNA/RNA oxidation) and urinary 8-isoprostane levels (a biomarker of lipid peroxidation) with type 2 diabetes incidence in 7,828 individuals initially without diabetes from a population-based German cohort study with 14 years of follow-up. Hazard ratios (HRs) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:31653645
DO  - DOI:10.2337/dc19-1379
UR  - https://inrepo02.dkfz.de/record/147387
ER  -