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@ARTICLE{Schttker:147387,
      author       = {B. Schöttker$^*$ and Y. Xuan$^*$ and X. Gào$^*$ and A.
                      Anusruti$^*$ and H. Brenner$^*$},
      title        = {{O}xidatively {D}amaged {DNA}/{RNA} and 8-{I}soprostane
                      {L}evels {A}re {A}ssociated {W}ith the {D}evelopment of
                      {T}ype 2 {D}iabetes at {O}lder {A}ge: {R}esults {F}rom a
                      {L}arge {C}ohort {S}tudy.},
      journal      = {Diabetes care},
      volume       = {43},
      number       = {1},
      issn         = {1935-5548},
      address      = {Alexandria, Va.},
      publisher    = {Assoc.},
      reportid     = {DKFZ-2019-02504},
      pages        = {130-136},
      year         = {2020},
      note         = {2020 Jan;43(1):130-136#EA:C070#LA:C070#},
      abstract     = {Oxidative stress is believed to play an important role in
                      the pathophysiology of type 2 diabetes, but the few cohort
                      studies that have assessed the association of oxidative
                      stress biomarkers with type 2 diabetes incidence were small
                      and reported inconclusive results.We examined the
                      associations of urinary oxidized guanine/guanosine (OxGua)
                      levels (a biomarker of DNA/RNA oxidation) and urinary
                      8-isoprostane levels (a biomarker of lipid peroxidation)
                      with type 2 diabetes incidence in 7,828 individuals
                      initially without diabetes from a population-based German
                      cohort study with 14 years of follow-up. Hazard ratios (HRs)
                      and $95\%$ CIs per 1 SD were obtained using
                      multivariable-adjusted Cox proportional hazards regression
                      models.In the total population, weak but statistically
                      significant associations with type 2 diabetes incidence were
                      observed for OxGua (HR $[95\%$ CI] per 1 SD 1.05 [1.01;
                      1.09]) and 8-isoprostane (1.04 [1.00; 1.09]) levels.
                      Stratified analyses showed that associations of both
                      biomarkers with type 2 diabetes incidence were absent in the
                      youngest age-group (50-59 years) and strongest in the oldest
                      age-group (65-75 years) of the cohort, with HRs of OxGua
                      levels of 1.14 (1.05; 1.23) per 1 SD and of 8-isoprostane
                      levels of 1.22 (1.02; 1.45) per 1 SD.These results from a
                      large cohort study support suggestions that an imbalanced
                      redox system contributes to the development of type 2
                      diabetes but suggest that this association becomes
                      clinically apparent at older ages only, possibly as a result
                      of reduced cellular repair capacity.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31653645},
      doi          = {10.2337/dc19-1379},
      url          = {https://inrepo02.dkfz.de/record/147387},
}