% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Stock:147393,
      author       = {A. Stock and M. Mynarek and T. Pietsch and S. M.
                      Pfister$^*$ and S. C. Clifford and T. Goschzik and D. Sturm
                      and E. C. Schwalbe and D. Hicks and S. Rutkowski and B.
                      Bison and M. Pham and M. Warmuth-Metz},
      title        = {{I}maging {C}haracteristics of {W}ingless {P}athway
                      {S}ubgroup {M}edulloblastomas: {R}esults from the {G}erman
                      {HIT}/{SIOP}-{T}rial {C}ohort.},
      journal      = {American journal of neuroradiology},
      volume       = {40},
      number       = {11},
      issn         = {1936-959X},
      address      = {Oak Brook, Ill.},
      publisher    = {Soc.},
      reportid     = {DKFZ-2019-02510},
      pages        = {1811-1817},
      year         = {2019},
      note         = {40(11):1811-1817},
      abstract     = {In addition to the 4 histopathologically defined entities
                      of medulloblastoma, 4 distinct genetically defined subgroups
                      have been included in the World Health Organization
                      classification of 2016. The smallest subgroup is the
                      medulloblastoma with activated wingless pathway. The goal of
                      this study was to identify a typical MR imaging morphology
                      in a larger number of pediatric patients with wingless
                      pathway medulloblastoma.From January 2001 to October 2017,
                      of 75 patients with histologically confirmed and molecularly
                      subgrouped wingless pathway medulloblastomas recruited to
                      the German Pediatric Brain Tumor (HIT) trials, 38 patients
                      (median age, 12.8 ± 4.6 years at diagnosis; 24 $[63.2\%]$
                      female) had preoperative imaging that passed the entry
                      criteria for this study. Images were rated by the local
                      standardized imaging criteria of the National Reference
                      Center of Neuroradiology. Additionally, a modified
                      laterality score was used to determine tumor localization
                      and extension.Twenty-eight of 38 $(73.7\%)$ were primary
                      midline tumors but with a lateral tendency in $39.3\%.$ One
                      extensively eccentric midline tumor was rated by the
                      laterality score as in an off-midline position. Five tumors
                      were found in the cerebellopontine angle; 3, in the deep
                      white matter; and 2, in a cerebellar hemisphere.
                      Leptomeningeal dissemination was rare $(11.5\%).$ In
                      $60.5\%,$ intratumoral blood-degradation products were
                      found, and $26.3\%$ showed cysts with blood
                      contents.According to our observations, wingless pathway
                      medulloblastomas are not preferentially off-midline tumors
                      as postulated in previous studies with smaller wingless
                      pathway medulloblastoma cohorts. Dense intratumoral
                      blood-degradation products and cysts with blood contents are
                      frequently found and might help to differentiate wingless
                      pathway medulloblastoma from other medulloblastoma
                      subtypes.},
      cin          = {B062 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31649159},
      doi          = {10.3174/ajnr.A6286},
      url          = {https://inrepo02.dkfz.de/record/147393},
}