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000147394 1001_ $$0P:(DE-He78)856d5c1d0205a79190ed88218ffaf9b2$$aReinhardt, Annekathrin$$b0$$eFirst author$$udkfz
000147394 245__ $$aTumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities.
000147394 260__ $$aLondon$$bBiomed Central$$c2019
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000147394 520__ $$aIn this multi-institutional study we compiled a retrospective cohort of 86 posterior fossa tumors having received the diagnosis of cerebellar glioblastoma (cGBM). All tumors were reviewed histologically and subjected to array-based methylation analysis followed by algorithm-based classification into distinct methylation classes (MCs). The single MC containing the largest proportion of 25 tumors diagnosed as cGBM was MC anaplastic astrocytoma with piloid features representing a recently-described molecular tumor entity not yet included in the WHO Classification of Tumours of the Central Nervous System (WHO classification). Twenty-nine tumors molecularly corresponded to either of 6 methylation subclasses subsumed in the MC family GBM IDH wildtype. Further we identified 6 tumors belonging to the MC diffuse midline glioma H3 K27 M mutant and 6 tumors allotted to the MC IDH mutant glioma subclass astrocytoma. Two tumors were classified as MC pilocytic astrocytoma of the posterior fossa, one as MC CNS high grade neuroepithelial tumor with BCOR alteration and one as MC control tissue, inflammatory tumor microenvironment. The methylation profiles of 16 tumors could not clearly be assigned to one distinct MC. In comparison to supratentorial localization, the MC GBM IDH wildtype subclass midline was overrepresented, whereas the MCs GBM IDH wildtype subclass mesenchymal and subclass RTK II were underrepresented in the cerebellum. Based on the integration of molecular and histological findings all tumors received an integrated diagnosis in line with the WHO classification 2016. In conclusion, cGBM does not represent a molecularly uniform tumor entity, but rather comprises different brain tumor entities with diverse prognosis and therapeutic options. Distinction of these molecular tumor classes requires molecular analysis. More than 30% of tumors diagnosed as cGBM belong to the recently described molecular entity of anaplastic astrocytoma with piloid features.
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000147394 7001_ $$0P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aStichel, Damian$$b1$$udkfz
000147394 7001_ $$0P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc$$aSchrimpf, Daniel$$b2$$udkfz
000147394 7001_ $$0P:(DE-HGF)0$$aKoelsche, Christian$$b3
000147394 7001_ $$0P:(DE-He78)32977c5abc127b0373ece54294a41f63$$aWefers, Annika K$$b4$$udkfz
000147394 7001_ $$0P:(DE-He78)c1e6f8388afe92ba3e13be35e7bf54d8$$aEbrahimi, Azadeh$$b5$$udkfz
000147394 7001_ $$0P:(DE-He78)8aad075b17d93a5636a34942bdbd7ee6$$aSievers, Philipp$$b6$$udkfz
000147394 7001_ $$0P:(DE-HGF)0$$aHuang, Kristin$$b7
000147394 7001_ $$0P:(DE-He78)1e5010244cbd57412baa2f0e2806a182$$aCasalini, M Belén$$b8$$udkfz
000147394 7001_ $$0P:(DE-HGF)0$$aFernández-Klett, Francisco$$b9
000147394 7001_ $$0P:(DE-He78)c77fccff3e6c42b017b2e8a09813590c$$aSuwala, Abigail$$b10$$udkfz
000147394 7001_ $$aWeller, Michael$$b11
000147394 7001_ $$aGramatzki, Dorothee$$b12
000147394 7001_ $$aFelsberg, Joerg$$b13
000147394 7001_ $$0P:(DE-HGF)0$$aReifenberger, Guido$$b14
000147394 7001_ $$aBecker, Albert$$b15
000147394 7001_ $$aHans, Volkmar H$$b16
000147394 7001_ $$aPrinz, Marco$$b17
000147394 7001_ $$aStaszewski, Ori$$b18
000147394 7001_ $$aAcker, Till$$b19
000147394 7001_ $$aDohmen, Hildegard$$b20
000147394 7001_ $$aHartmann, Christian$$b21
000147394 7001_ $$aPaulus, Werner$$b22
000147394 7001_ $$aHeß, Katharina$$b23
000147394 7001_ $$aBrokinkel, Benjamin$$b24
000147394 7001_ $$aSchittenhelm, Jens$$b25
000147394 7001_ $$aBuslei, Rolf$$b26
000147394 7001_ $$aDeckert, Martina$$b27
000147394 7001_ $$aMawrin, Christian$$b28
000147394 7001_ $$aHewer, Ekkehard$$b29
000147394 7001_ $$aPohl, Ute$$b30
000147394 7001_ $$aJaunmuktane, Zane$$b31
000147394 7001_ $$aBrandner, Sebastian$$b32
000147394 7001_ $$aUnterberg, Andreas$$b33
000147394 7001_ $$aHänggi, Daniel$$b34
000147394 7001_ $$0P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5$$aPlatten, Michael$$b35$$udkfz
000147394 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b36$$udkfz
000147394 7001_ $$aWick, Wolfgang$$b37
000147394 7001_ $$aHerold-Mende, Christel$$b38
000147394 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b39$$udkfz
000147394 7001_ $$0P:(DE-HGF)0$$aReuss, David E$$b40
000147394 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b41$$udkfz
000147394 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David T W$$b42$$udkfz
000147394 7001_ $$0P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c$$aCapper, David$$b43$$udkfz
000147394 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b44$$eLast author$$udkfz
000147394 773__ $$0PERI:(DE-600)2715589-4$$a10.1186/s40478-019-0801-8$$gVol. 7, no. 1, p. 163$$n1$$p163$$tActa Neuropathologica Communications$$v7$$x2051-5960$$y2019
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