TY  - JOUR
AU  - Reinhardt, Annekathrin
AU  - Stichel, Damian
AU  - Schrimpf, Daniel
AU  - Koelsche, Christian
AU  - Wefers, Annika K
AU  - Ebrahimi, Azadeh
AU  - Sievers, Philipp
AU  - Huang, Kristin
AU  - Casalini, M Belén
AU  - Fernández-Klett, Francisco
AU  - Suwala, Abigail
AU  - Weller, Michael
AU  - Gramatzki, Dorothee
AU  - Felsberg, Joerg
AU  - Reifenberger, Guido
AU  - Becker, Albert
AU  - Hans, Volkmar H
AU  - Prinz, Marco
AU  - Staszewski, Ori
AU  - Acker, Till
AU  - Dohmen, Hildegard
AU  - Hartmann, Christian
AU  - Paulus, Werner
AU  - Heß, Katharina
AU  - Brokinkel, Benjamin
AU  - Schittenhelm, Jens
AU  - Buslei, Rolf
AU  - Deckert, Martina
AU  - Mawrin, Christian
AU  - Hewer, Ekkehard
AU  - Pohl, Ute
AU  - Jaunmuktane, Zane
AU  - Brandner, Sebastian
AU  - Unterberg, Andreas
AU  - Hänggi, Daniel
AU  - Platten, Michael
AU  - Pfister, Stefan M
AU  - Wick, Wolfgang
AU  - Herold-Mende, Christel
AU  - Korshunov, Andrey
AU  - Reuss, David E
AU  - Sahm, Felix
AU  - Jones, David T W
AU  - Capper, David
AU  - von Deimling, Andreas
TI  - Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities.
JO  - Acta Neuropathologica Communications
VL  - 7
IS  - 1
SN  - 2051-5960
CY  - London
PB  - Biomed Central
M1  - DKFZ-2019-02511
SP  - 163
PY  - 2019
N1  - EA:B300LA:B300
AB  - In this multi-institutional study we compiled a retrospective cohort of 86 posterior fossa tumors having received the diagnosis of cerebellar glioblastoma (cGBM). All tumors were reviewed histologically and subjected to array-based methylation analysis followed by algorithm-based classification into distinct methylation classes (MCs). The single MC containing the largest proportion of 25 tumors diagnosed as cGBM was MC anaplastic astrocytoma with piloid features representing a recently-described molecular tumor entity not yet included in the WHO Classification of Tumours of the Central Nervous System (WHO classification). Twenty-nine tumors molecularly corresponded to either of 6 methylation subclasses subsumed in the MC family GBM IDH wildtype. Further we identified 6 tumors belonging to the MC diffuse midline glioma H3 K27 M mutant and 6 tumors allotted to the MC IDH mutant glioma subclass astrocytoma. Two tumors were classified as MC pilocytic astrocytoma of the posterior fossa, one as MC CNS high grade neuroepithelial tumor with BCOR alteration and one as MC control tissue, inflammatory tumor microenvironment. The methylation profiles of 16 tumors could not clearly be assigned to one distinct MC. In comparison to supratentorial localization, the MC GBM IDH wildtype subclass midline was overrepresented, whereas the MCs GBM IDH wildtype subclass mesenchymal and subclass RTK II were underrepresented in the cerebellum. Based on the integration of molecular and histological findings all tumors received an integrated diagnosis in line with the WHO classification 2016. In conclusion, cGBM does not represent a molecularly uniform tumor entity, but rather comprises different brain tumor entities with diverse prognosis and therapeutic options. Distinction of these molecular tumor classes requires molecular analysis. More than 30
LB  - PUB:(DE-HGF)16
C6  - pmid:31661039
C2  - pmc:PMC6816155
DO  - DOI:10.1186/s40478-019-0801-8
UR  - https://inrepo02.dkfz.de/record/147394
ER  -