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@ARTICLE{Bendinger:147492,
      author       = {A. Bendinger$^*$ and L. Seyler and M. Saager$^*$ and C.
                      Debus and P. Peschke and D. Komljenovic$^*$ and J. Debus$^*$
                      and J. Peter$^*$ and R. O. Floca$^*$ and C. P. Karger$^*$
                      and C. Glowa$^*$},
      title        = {{I}mpact of {S}ingle {D}ose {P}hotons and {C}arbon {I}ons
                      on {P}erfusion and {V}ascular {P}ermeability: {A} {D}ynamic
                      {C}ontrast-{E}nhanced {MRI} {P}ilot {S}tudy in the
                      {A}naplastic {R}at {P}rostate {T}umor {R}3327-{AT}1.},
      journal      = {Radiation research},
      volume       = {193},
      number       = {1},
      issn         = {0033-7587},
      address      = {Great Falls, Va.},
      publisher    = {Radiation Research Society},
      reportid     = {DKFZ-2019-02548},
      pages        = {34-45},
      year         = {2020},
      note         = {2020 Jan;193(1):34-45#EA:E040#LA:E040#},
      abstract     = {We collected initial quantitative information on the
                      effects of high-dose carbon (12C) ions compared to photons
                      on vascular damage in anaplastic rat prostate tumors, with
                      the goal of elucidating differences in response to high-LET
                      radiation, using dynamic contrast-enhanced magnetic
                      resonance imaging (DCE-MRI). Syngeneic R3327-AT1 rat
                      prostate tumors received a single dose of either 16 or 37 Gy
                      12C ions or 37 or 85 Gy 6 MV photons (iso-absorbed and
                      iso-effective doses, respectively). The animals underwent
                      DCE-MRI prior to, and on days 3, 7, 14 and 21
                      postirradiation. The extended Tofts model was used for
                      pharmacokinetic analysis. At day 21, tumors were dissected
                      and histologically examined. The results of this work showed
                      the following: 1. 12C ions led to stronger vascular changes
                      compared to photons, independent of dose; 2. Tumor growth
                      was comparable for all radiation doses and modalities until
                      day 21; 3. Nonirradiated, rapidly growing control tumors
                      showed a decrease in all pharmacokinetic parameters (area
                      under the curve, Ktrans, ve, vp) over time; 4.
                      12C-ion-irradiated tumors showed an earlier increase in area
                      under the curve and Ktrans than photon-irradiated tumors; 5.
                      12C-ion irradiation resulted in more homogeneous parameter
                      maps and histology compared to photons; and 6. 12C-ion
                      irradiation led to an increased microvascular density and
                      decreased proliferation activity in a largely
                      dose-independent manner compared to photons. Postirradiation
                      changes related to 12C ions and photons were detected using
                      DCE-MRI, and correlated with histological parameters in an
                      anaplastic experimental prostate tumor. In summary, this
                      pilot study demonstrated that exposure to 12C ions increased
                      the perfusion and/or permeability faster and led to larger
                      changes in DCE-MRI parameters resulting in increased vessel
                      density and presumably less hypoxia at the end of the
                      observation period when compared to photons. Within this
                      study no differences were found between curative and
                      sub-curative doses in either modality.},
      cin          = {E040 / E020 / E050 / E230},
      ddc          = {530},
      cid          = {I:(DE-He78)E040-20160331 / I:(DE-He78)E020-20160331 /
                      I:(DE-He78)E050-20160331 / I:(DE-He78)E230-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31697210},
      doi          = {10.1667/RR15459.1},
      url          = {https://inrepo02.dkfz.de/record/147492},
}