TY  - JOUR
AU  - Jung, Audrey Ying-Chee
AU  - Behrens, Sabine
AU  - Schmidt, Martina
AU  - Thoene, Kathrin
AU  - Obi, Nadia
AU  - Hüsing, Anika
AU  - Benner, Axel
AU  - Steindorf, Karen
AU  - Chang-Claude, Jenny
TI  - Pre- to postdiagnosis leisure-time physical activity and prognosis in postmenopausal breast cancer survivors.
JO  - Breast cancer research
VL  - 21
IS  - 1
SN  - 1465-542X
CY  - London
PB  - BioMed Central
M1  - DKFZ-2019-02553
SP  - 117
PY  - 2019
AB  - Physical activity (PA) before and after breast cancer diagnosis has been reported to be associated with lower mortality. However, whether changes in the activity after diagnosis impact prognosis is unclear and has not received much attention. This study aimed to examine pre- to postdiagnosis leisure-time PA and breast cancer prognosis.We used data from the MARIE study, a prospective population-based patient cohort study of 3813 postmenopausal breast cancer patients, aged 50-74 at diagnosis, recruited from 2002 to 2005, re-interviewed in 2009, and followed up until June 2015. Prediagnosis PA was assessed at recruitment; postdiagnosis PA was assessed at re-interview in 2009. To examine pre- to postdiagnosis change in PA, women were categorized by pre- and postdiagnosis PA using a cut-off of 7.5 MET-h/week for meeting PA recommendations and combined into four groups: insufficiently active, increasingly active, decreasingly active, and sufficiently active. Cox regression models with delayed entry were used to assess associations between pre- to postdiagnosis patterns of PA and overall mortality (OM), breast cancer mortality (BCM), and recurrence-free survival (RFS). Additional analyses of pre- and postdiagnosis PA (no activity (reference), low activity, sufficient activity) with cancer outcomes, such as using a time-dependent model, were performed. In total, 2042 patients were included in the analyses.There were 206 deaths (114 from breast cancer) after a median follow-up time of 6.0 years after the 2009 interview. Compared to insufficiently active women, increasingly active women were at lower risk of OM, BCM, and RFS (HR (95
LB  - PUB:(DE-HGF)16
C6  - pmid:31694687
C2  - pmc:PMC6836389
DO  - DOI:10.1186/s13058-019-1206-0
UR  - https://inrepo02.dkfz.de/record/147497
ER  -