%0 Journal Article
%A Ebert, Helen
%A Lacruz, Maria Elena
%A Kluttig, Alexander
%A Simm, Andreas
%A Greiser, Karin Halina
%A Tiller, Daniel
%A Kartschmit, Nadja
%A Mikolajczyk, Rafael
%T Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort.
%J BMC geriatrics
%V 19
%N 1
%@ 1471-2318
%C London
%I BioMed Central
%M DKFZ-2019-02564
%P 299
%D 2019
%X Advanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent studies suggested that the ratio of AGEs and their soluble receptor (sRAGE) is a more accurate biomarker for age-related diseases than each separately. We aim to investigate whether this also applies for physical functioning in a broad age-spectrum.AGE and sRAGE levels, and physical functioning (SF-12 questionnaire) of 967 men and 812 women (45-83 years) were measured in the CARLA study. We used ordinal logistic regression to examine associations between AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning in sex- and age-stratified models.Higher levels of AGEs and AGE/sRAGE ratio were associated with lower physical functioning only in women, even after consideration of classical lifestyle and age-related factors (education, BMI, smoking, alcohol consumption, diet, creatinine clearance, diabetes mellitus, lipid lowering and antihypertensive drugs) (odds ratio (OR) =0.86, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31684879
%2 pmc:PMC6829799
%R 10.1186/s12877-019-1323-8
%U https://inrepo02.dkfz.de/record/147510