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000147510 1001_ $$aEbert, Helen$$b0
000147510 245__ $$aAdvanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort.
000147510 260__ $$aLondon$$bBioMed Central$$c2019
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000147510 520__ $$aAdvanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent studies suggested that the ratio of AGEs and their soluble receptor (sRAGE) is a more accurate biomarker for age-related diseases than each separately. We aim to investigate whether this also applies for physical functioning in a broad age-spectrum.AGE and sRAGE levels, and physical functioning (SF-12 questionnaire) of 967 men and 812 women (45-83 years) were measured in the CARLA study. We used ordinal logistic regression to examine associations between AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning in sex- and age-stratified models.Higher levels of AGEs and AGE/sRAGE ratio were associated with lower physical functioning only in women, even after consideration of classical lifestyle and age-related factors (education, BMI, smoking, alcohol consumption, diet, creatinine clearance, diabetes mellitus, lipid lowering and antihypertensive drugs) (odds ratio (OR) =0.86, 95%confidence interval = 0.74-0.98 and OR = 0.86, 95%CI = 0.75-0.98 for AGEs and AGE/sRAGE ratio respectively). We could not demonstrate a significant difference across age.We showed a sex-specific association between physical functioning and AGEs and AGE/sRAGE, but no stronger associations of the latter with physical functioning. Further investigation is needed in the pathophysiology of this association.
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000147510 7001_ $$aLacruz, Maria Elena$$b1
000147510 7001_ $$aKluttig, Alexander$$b2
000147510 7001_ $$aSimm, Andreas$$b3
000147510 7001_ $$0P:(DE-He78)e0ac0d57cdb66d87f2d95ae5f6178c1b$$aGreiser, Karin Halina$$b4$$udkfz
000147510 7001_ $$aTiller, Daniel$$b5
000147510 7001_ $$aKartschmit, Nadja$$b6
000147510 7001_ $$00000-0003-1271-7204$$aMikolajczyk, Rafael$$b7
000147510 773__ $$0PERI:(DE-600)2059865-8$$a10.1186/s12877-019-1323-8$$gVol. 19, no. 1, p. 299$$n1$$p299$$tBMC geriatrics$$v19$$x1471-2318$$y2019
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