TY  - JOUR
AU  - Ebert, Helen
AU  - Lacruz, Maria Elena
AU  - Kluttig, Alexander
AU  - Simm, Andreas
AU  - Greiser, Karin Halina
AU  - Tiller, Daniel
AU  - Kartschmit, Nadja
AU  - Mikolajczyk, Rafael
TI  - Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort.
JO  - BMC geriatrics
VL  - 19
IS  - 1
SN  - 1471-2318
CY  - London
PB  - BioMed Central
M1  - DKFZ-2019-02564
SP  - 299
PY  - 2019
AB  - Advanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent studies suggested that the ratio of AGEs and their soluble receptor (sRAGE) is a more accurate biomarker for age-related diseases than each separately. We aim to investigate whether this also applies for physical functioning in a broad age-spectrum.AGE and sRAGE levels, and physical functioning (SF-12 questionnaire) of 967 men and 812 women (45-83 years) were measured in the CARLA study. We used ordinal logistic regression to examine associations between AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning in sex- and age-stratified models.Higher levels of AGEs and AGE/sRAGE ratio were associated with lower physical functioning only in women, even after consideration of classical lifestyle and age-related factors (education, BMI, smoking, alcohol consumption, diet, creatinine clearance, diabetes mellitus, lipid lowering and antihypertensive drugs) (odds ratio (OR) =0.86, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:31684879
C2  - pmc:PMC6829799
DO  - DOI:10.1186/s12877-019-1323-8
UR  - https://inrepo02.dkfz.de/record/147510
ER  -