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@ARTICLE{Ebert:147510,
      author       = {H. Ebert and M. E. Lacruz and A. Kluttig and A. Simm and K.
                      H. Greiser$^*$ and D. Tiller and N. Kartschmit and R.
                      Mikolajczyk},
      title        = {{A}dvanced glycation end products and their ratio to
                      soluble receptor are associated with limitations in physical
                      functioning only in women: results from the {CARLA} cohort.},
      journal      = {BMC geriatrics},
      volume       = {19},
      number       = {1},
      issn         = {1471-2318},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2019-02564},
      pages        = {299},
      year         = {2019},
      abstract     = {Advanced glycation end products (AGEs), modifications of
                      proteins or amino acids, are increasingly produced and
                      accumulated with age-related diseases. Recent studies
                      suggested that the ratio of AGEs and their soluble receptor
                      (sRAGE) is a more accurate biomarker for age-related
                      diseases than each separately. We aim to investigate whether
                      this also applies for physical functioning in a broad
                      age-spectrum.AGE and sRAGE levels, and physical functioning
                      (SF-12 questionnaire) of 967 men and 812 women
                      (45-83 years) were measured in the CARLA study. We used
                      ordinal logistic regression to examine associations between
                      AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning
                      in sex- and age-stratified models.Higher levels of AGEs and
                      AGE/sRAGE ratio were associated with lower physical
                      functioning only in women, even after consideration of
                      classical lifestyle and age-related factors (education, BMI,
                      smoking, alcohol consumption, diet, creatinine clearance,
                      diabetes mellitus, lipid lowering and antihypertensive
                      drugs) (odds ratio (OR) =0.86, $95\%confidence$
                      interval = 0.74-0.98 and OR = 0.86,
                      $95\%CI = 0.75-0.98$ for AGEs and AGE/sRAGE ratio
                      respectively). We could not demonstrate a significant
                      difference across age.We showed a sex-specific association
                      between physical functioning and AGEs and AGE/sRAGE, but no
                      stronger associations of the latter with physical
                      functioning. Further investigation is needed in the
                      pathophysiology of this association.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31684879},
      pmc          = {pmc:PMC6829799},
      doi          = {10.1186/s12877-019-1323-8},
      url          = {https://inrepo02.dkfz.de/record/147510},
}