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| 024 | 7 | _ | |a 10.1186/s12877-019-1323-8 |2 doi |
| 024 | 7 | _ | |a pmid:31684879 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6829799 |2 pmc |
| 037 | _ | _ | |a DKFZ-2019-02564 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Ebert, Helen |b 0 |
| 245 | _ | _ | |a Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort. |
| 260 | _ | _ | |a London |c 2019 |b BioMed Central |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1573634263_20580 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Advanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent studies suggested that the ratio of AGEs and their soluble receptor (sRAGE) is a more accurate biomarker for age-related diseases than each separately. We aim to investigate whether this also applies for physical functioning in a broad age-spectrum.AGE and sRAGE levels, and physical functioning (SF-12 questionnaire) of 967 men and 812 women (45-83 years) were measured in the CARLA study. We used ordinal logistic regression to examine associations between AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning in sex- and age-stratified models.Higher levels of AGEs and AGE/sRAGE ratio were associated with lower physical functioning only in women, even after consideration of classical lifestyle and age-related factors (education, BMI, smoking, alcohol consumption, diet, creatinine clearance, diabetes mellitus, lipid lowering and antihypertensive drugs) (odds ratio (OR) =0.86, 95%confidence interval = 0.74-0.98 and OR = 0.86, 95%CI = 0.75-0.98 for AGEs and AGE/sRAGE ratio respectively). We could not demonstrate a significant difference across age.We showed a sex-specific association between physical functioning and AGEs and AGE/sRAGE, but no stronger associations of the latter with physical functioning. Further investigation is needed in the pathophysiology of this association. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Lacruz, Maria Elena |b 1 |
| 700 | 1 | _ | |a Kluttig, Alexander |b 2 |
| 700 | 1 | _ | |a Simm, Andreas |b 3 |
| 700 | 1 | _ | |a Greiser, Karin Halina |0 P:(DE-He78)e0ac0d57cdb66d87f2d95ae5f6178c1b |b 4 |u dkfz |
| 700 | 1 | _ | |a Tiller, Daniel |b 5 |
| 700 | 1 | _ | |a Kartschmit, Nadja |b 6 |
| 700 | 1 | _ | |a Mikolajczyk, Rafael |0 0000-0003-1271-7204 |b 7 |
| 773 | _ | _ | |a 10.1186/s12877-019-1323-8 |g Vol. 19, no. 1, p. 299 |0 PERI:(DE-600)2059865-8 |n 1 |p 299 |t BMC geriatrics |v 19 |y 2019 |x 1471-2318 |
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