TY  - JOUR
AU  - Niersmann, Corinna
AU  - Carstensen-Kirberg, Maren
AU  - Maalmi, Haifa
AU  - Holleczek, Bernd
AU  - Roden, Michael
AU  - Brenner, Hermann
AU  - Herder, Christian
AU  - Schöttker, Ben
TI  - Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes.
JO  - Diabetologia
VL  - 63
IS  - 2
SN  - 1432-0428
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2019-02576
SP  - 410-418
PY  - 2020
N1  - Diabetologia. 2020 Feb;63(2):410-418#LA:C070#
AB  - Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin concentrations are associated with increased risk of cardiovascular events in people with established diabetes. Therefore, the present study investigated the association between serum omentin concentrations and the risk of cardiovascular events in individuals with diabetes.This prospective study was based on participants of the German ESTHER cohort with diabetes and without previous cardiovascular event. The ESTHER cohort consists of individuals aged 50-75 years at baseline who were recruited by their general practitioners. After exclusion of individuals with serum C-reactive protein ≥10 mg/l (≥95.24 nmol/l), the final analysis population consisted of 933 individuals. At baseline, serum omentin concentrations were measured by ELISA. Cox regression models were fitted to estimate HRs and their corresponding 95
LB  - PUB:(DE-HGF)16
C6  - pmid:31705160
DO  - DOI:10.1007/s00125-019-05017-2
UR  - https://inrepo02.dkfz.de/record/147522
ER  -