%0 Journal Article
%A Chun, Hye-Jung E
%A Johann, Pascal D
%A Milne, Katy
%A Zapatka, Marc
%A Buellesbach, Annette
%A Ishaque, Naveed
%A Iskar, Murat
%A Erkek, Serap
%A Wei, Lisa
%A Tessier-Cloutier, Basile
%A Lever, Jake
%A Titmuss, Emma
%A Topham, James T
%A Bowlby, Reanne
%A Chuah, Eric
%A Mungall, Karen L
%A Ma, Yussanne
%A Mungall, Andrew J
%A Moore, Richard A
%A Taylor, Michael D
%A Gerhard, Daniela S
%A Jones, Steven J M
%A Korshunov, Andrey
%A Gessler, Manfred
%A Kerl, Kornelius
%A Hasselblatt, Martin
%A Frühwald, Michael C
%A Perlman, Elizabeth J
%A Nelson, Brad H
%A Pfister, Stefan M
%A Marra, Marco A
%A Kool, Marcel
%T Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.
%J Cell reports
%V 29
%N 8
%@ 2211-1247
%C [New York, NY]
%I Elsevier
%M DKFZ-2019-02581
%P 2338-2354.e7
%D 2019
%Z 29(8):2338-2354.e7
%X Extra-cranial malignant rhabdoid tumors (MRTs) and cranial atypical teratoid RTs (ATRTs) are heterogeneous pediatric cancers driven primarily by SMARCB1 loss. To understand the genome-wide molecular relationships between MRTs and ATRTs, we analyze multi-omics data from 140 MRTs and 161 ATRTs. We detect similarities between the MYC subgroup of ATRTs (ATRT-MYC) and extra-cranial MRTs, including global DNA hypomethylation and overexpression of HOX genes and genes involved in mesenchymal development, distinguishing them from other ATRT subgroups that express neural-like features. We identify five DNA methylation subgroups associated with anatomical sites and SMARCB1 mutation patterns. Groups 1, 3, and 4 exhibit cytotoxic T cell infiltration and expression of immune checkpoint regulators, consistent with a potential role for immunotherapy in rhabdoid tumor patients.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31708418
%R 10.1016/j.celrep.2019.10.013
%U https://inrepo02.dkfz.de/record/147527