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000147527 1001_ $$aChun, Hye-Jung E$$b0
000147527 245__ $$aIdentification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.
000147527 260__ $$a[New York, NY]$$bElsevier$$c2019
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000147527 520__ $$aExtra-cranial malignant rhabdoid tumors (MRTs) and cranial atypical teratoid RTs (ATRTs) are heterogeneous pediatric cancers driven primarily by SMARCB1 loss. To understand the genome-wide molecular relationships between MRTs and ATRTs, we analyze multi-omics data from 140 MRTs and 161 ATRTs. We detect similarities between the MYC subgroup of ATRTs (ATRT-MYC) and extra-cranial MRTs, including global DNA hypomethylation and overexpression of HOX genes and genes involved in mesenchymal development, distinguishing them from other ATRT subgroups that express neural-like features. We identify five DNA methylation subgroups associated with anatomical sites and SMARCB1 mutation patterns. Groups 1, 3, and 4 exhibit cytotoxic T cell infiltration and expression of immune checkpoint regulators, consistent with a potential role for immunotherapy in rhabdoid tumor patients.
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000147527 7001_ $$0P:(DE-He78)3fdc3623477264cb5d0e14f256dbfbb8$$aJohann, Pascal D$$b1
000147527 7001_ $$aMilne, Katy$$b2
000147527 7001_ $$0P:(DE-He78)1beba8f953e7ae7e96e8d3e9a48f10f7$$aZapatka, Marc$$b3
000147527 7001_ $$0P:(DE-HGF)0$$aBuellesbach, Annette$$b4
000147527 7001_ $$0P:(DE-He78)4096eeffdfc73b75e8ba63dc621a017d$$aIshaque, Naveed$$b5
000147527 7001_ $$0P:(DE-He78)f28fcc92d5c00f3ee511e3319c699b38$$aIskar, Murat$$b6
000147527 7001_ $$aErkek, Serap$$b7
000147527 7001_ $$aWei, Lisa$$b8
000147527 7001_ $$aTessier-Cloutier, Basile$$b9
000147527 7001_ $$aLever, Jake$$b10
000147527 7001_ $$aTitmuss, Emma$$b11
000147527 7001_ $$aTopham, James T$$b12
000147527 7001_ $$aBowlby, Reanne$$b13
000147527 7001_ $$aChuah, Eric$$b14
000147527 7001_ $$aMungall, Karen L$$b15
000147527 7001_ $$aMa, Yussanne$$b16
000147527 7001_ $$aMungall, Andrew J$$b17
000147527 7001_ $$aMoore, Richard A$$b18
000147527 7001_ $$aTaylor, Michael D$$b19
000147527 7001_ $$aGerhard, Daniela S$$b20
000147527 7001_ $$aJones, Steven J M$$b21
000147527 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b22$$udkfz
000147527 7001_ $$aGessler, Manfred$$b23
000147527 7001_ $$aKerl, Kornelius$$b24
000147527 7001_ $$aHasselblatt, Martin$$b25
000147527 7001_ $$aFrühwald, Michael C$$b26
000147527 7001_ $$aPerlman, Elizabeth J$$b27
000147527 7001_ $$aNelson, Brad H$$b28
000147527 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b29
000147527 7001_ $$aMarra, Marco A$$b30
000147527 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b31$$eLast author
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