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| Home > Publications database > Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration. > print |
| Home > Publications database > Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration. > print |
| 001 | 147527 | ||
| 005 | 20240229112652.0 | ||
| 024 | 7 | _ | |a 10.1016/j.celrep.2019.10.013 |2 doi |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Chun, Hye-Jung E |b 0 |
| 245 | _ | _ | |a Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration. |
| 260 | _ | _ | |a [New York, NY] |c 2019 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1576853832_13817 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 29(8):2338-2354.e7 |
| 520 | _ | _ | |a Extra-cranial malignant rhabdoid tumors (MRTs) and cranial atypical teratoid RTs (ATRTs) are heterogeneous pediatric cancers driven primarily by SMARCB1 loss. To understand the genome-wide molecular relationships between MRTs and ATRTs, we analyze multi-omics data from 140 MRTs and 161 ATRTs. We detect similarities between the MYC subgroup of ATRTs (ATRT-MYC) and extra-cranial MRTs, including global DNA hypomethylation and overexpression of HOX genes and genes involved in mesenchymal development, distinguishing them from other ATRT subgroups that express neural-like features. We identify five DNA methylation subgroups associated with anatomical sites and SMARCB1 mutation patterns. Groups 1, 3, and 4 exhibit cytotoxic T cell infiltration and expression of immune checkpoint regulators, consistent with a potential role for immunotherapy in rhabdoid tumor patients. |
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| 700 | 1 | _ | |a Johann, Pascal D |0 P:(DE-He78)3fdc3623477264cb5d0e14f256dbfbb8 |b 1 |
| 700 | 1 | _ | |a Milne, Katy |b 2 |
| 700 | 1 | _ | |a Zapatka, Marc |0 P:(DE-He78)1beba8f953e7ae7e96e8d3e9a48f10f7 |b 3 |
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| 700 | 1 | _ | |a Ishaque, Naveed |0 P:(DE-He78)4096eeffdfc73b75e8ba63dc621a017d |b 5 |
| 700 | 1 | _ | |a Iskar, Murat |0 P:(DE-He78)f28fcc92d5c00f3ee511e3319c699b38 |b 6 |
| 700 | 1 | _ | |a Erkek, Serap |b 7 |
| 700 | 1 | _ | |a Wei, Lisa |b 8 |
| 700 | 1 | _ | |a Tessier-Cloutier, Basile |b 9 |
| 700 | 1 | _ | |a Lever, Jake |b 10 |
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| 700 | 1 | _ | |a Topham, James T |b 12 |
| 700 | 1 | _ | |a Bowlby, Reanne |b 13 |
| 700 | 1 | _ | |a Chuah, Eric |b 14 |
| 700 | 1 | _ | |a Mungall, Karen L |b 15 |
| 700 | 1 | _ | |a Ma, Yussanne |b 16 |
| 700 | 1 | _ | |a Mungall, Andrew J |b 17 |
| 700 | 1 | _ | |a Moore, Richard A |b 18 |
| 700 | 1 | _ | |a Taylor, Michael D |b 19 |
| 700 | 1 | _ | |a Gerhard, Daniela S |b 20 |
| 700 | 1 | _ | |a Jones, Steven J M |b 21 |
| 700 | 1 | _ | |a Korshunov, Andrey |0 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |b 22 |u dkfz |
| 700 | 1 | _ | |a Gessler, Manfred |b 23 |
| 700 | 1 | _ | |a Kerl, Kornelius |b 24 |
| 700 | 1 | _ | |a Hasselblatt, Martin |b 25 |
| 700 | 1 | _ | |a Frühwald, Michael C |b 26 |
| 700 | 1 | _ | |a Perlman, Elizabeth J |b 27 |
| 700 | 1 | _ | |a Nelson, Brad H |b 28 |
| 700 | 1 | _ | |a Pfister, Stefan M |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 29 |
| 700 | 1 | _ | |a Marra, Marco A |b 30 |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 31 |e Last author |
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