%0 Journal Article
%A Rolandsson, Olov
%A Hampe, Christiane S
%A Sharp, Stephen J
%A Ardanaz, Eva
%A Boeing, Heiner
%A Fagherazzi, Guy
%A Mancini, Francesca Romana
%A Nilsson, Peter M
%A Overvad, Kim
%A Chirlaque, Maria-Dolores
%A Dorronsoro, Miren
%A Gunter, Marc J
%A Kaaks, Rudolf
%A Key, Timothy J
%A Khaw, Kay-Tee
%A Krogh, Vittorio
%A Kühn, Tilman
%A Palli, Domenico
%A Panico, Salvatore
%A Sacerdote, Carlotta
%A Sánchez, Maria-José
%A Severi, Gianluca
%A Spijkerman, Annemieke M W
%A Tumino, Rosario
%A van der Schouw, Yvonne T
%A Riboli, Elio
%A Forouhi, Nita G
%A Langenberg, Claudia
%A Wareham, Nicholas J
%T Autoimmunity plays a role in the onset of diabetes after 40 years of age.
%J Diabetologia
%V 63
%N 2
%@ 1432-0428
%C Heidelberg
%I Springer
%M DKFZ-2019-02606
%P 266-277
%D 2020
%Z  2020 Feb;63(2):266-277
%X Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes. However, there are relatively few prospective studies that have characterised the relationship between autoimmunity and incident diabetes. We investigated associations of antibodies against the 65 kDa isoform of GAD (GAD65) with type 1 diabetes and type 2 diabetes genetic risk scores and incident diabetes in adults in European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a case-cohort study nested in the EPIC cohort.GAD65 antibodies were analysed in EPIC participants (over 40 years of age and free of known diabetes at baseline) by radioligand binding assay in a random subcohort (n = 15,802) and in incident diabetes cases (n = 11,981). Type 1 diabetes and type 2 diabetes genetic risk scores were calculated. Associations between GAD65 antibodies and incident diabetes were estimated using Prentice-weighted Cox regression.GAD65 antibody positivity at baseline was associated with development of diabetes during a median follow-up time of 10.9 years (HR for GAD65 antibody positive vs negative 1.78; 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31713011
%R 10.1007/s00125-019-05016-3
%U https://inrepo02.dkfz.de/record/147615