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@ARTICLE{Akdad:147634,
      author       = {M. Akdad and M. Ajebli and A. Breuer$^*$ and F. Khallouki
                      and R. W. Owen$^*$ and M. Eddouks},
      title        = {{S}tudy of antihypertensive activity of {A}nvillea radiata
                      in {L}-{NAME}-induced hypertensive rats and
                      {HPLC}-{ESI}-{MS} analysis.},
      journal      = {Endocrine, metabolic $\&$ immune disorders, drug targets},
      volume       = {20},
      number       = {7},
      issn         = {1871-5303},
      address      = {Sharjah},
      publisher    = {Bentham Science Publ.},
      reportid     = {DKFZ-2019-02625},
      pages        = {1059-1072},
      year         = {2020},
      note         = {2020;20(7):1059-1072},
      abstract     = {This study aimed to evaluate the effect of the aqueous
                      extract of Anvillea radiate (A. radiata) aerial parts (AEAR)
                      on arterial blood pressure in normotensive and hypertensive
                      rats.The effect of the acute and sub-chronic administration
                      of AEAR on the following blood pressure parameters: systolic
                      blood pressure (SBP), mean blood pressure (MBP), diastolic
                      blood pressure (DBP), and heart rate (HR) was evaluated in
                      normotensive and L-NAME induced hypertensive rats. In the
                      second experiment the vasorelaxant effect of AEAR was
                      assessed in isolated rat aortic rings with functional
                      endothelium pre-contracted with epinephrine (EP) or KCl, and
                      six antagonists/inhibitors were used to explore the
                      mechanisms of action involved in the vasorelaxant effect. In
                      order to determine the phytochemical contents of Anvillea
                      radiata HPLC-ESI-MS analysis was conducted.Daily oral
                      administration of AEAR (100 mg/kg) provoked a significant
                      decrease in SBP, MBP, and DBP without affecting HR in
                      hypertensive rats. In addition, AEAR (0.08-0.64 mg/ml)
                      revealed a vasorelaxant effect in thoracic aortic rings
                      pre-contracted by EP (10 µM) or KCl (80 mM). This effect
                      was reduced in the presence of Nifedipine, L-Name or
                      Methylene blue. The polyphenolic compounds of AEAR were
                      determined.This study revealed that AEAR possesses a potent
                      antihypertensive activity and its vasorelaxant activity
                      seems to be mediated through Ca2+ channels, direct nitric
                      oxide (NO), and NO/cGMP pathways. Chlorogenic acid and
                      caffeic acid identified in A. radiata could be at least
                      partially responsible for the antihypertensive activity of
                      this extract.},
      cin          = {C120},
      cid          = {I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31729295},
      doi          = {10.2174/1871530319666191115114023},
      url          = {https://inrepo02.dkfz.de/record/147634},
}