%0 Journal Article
%A Laetsch, Dana Clarissa
%A Hoppe, Liesa Katharina
%A Saum, Kai-Uwe
%A Haefeli, Walter E
%A Brenner, Hermann
%A Schöttker, Ben
%T Investigation of a possible association of potentially inappropriate medication for older adults and frailty in a prospective cohort study from Germany.
%J Age & ageing
%V 49
%N 1
%@ 1468-2834
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2019-02637
%P 20-25
%D 2019
%Z 2019 Dec 1;49(1):20-25
%X potentially inappropriate medications (PIMs) are commonly defined as drugs that should be avoided in older adults because they are considered to have a negative risk-benefit ratio. PIMs are suspected to increase the risk for frailty, but this has yet to be examined.prospective population-based cohort study.a German cohort of community-dwelling older adults (≥60 years) was followed from October 2008 to September 2016.in propensity score-adjusted logistic and Cox regression models, associations between baseline PIM use and prevalent/incident frailty were investigated. Frailty was assessed using the definition by Fried and co-workers, PIM were defined with the 2015 BEERS criteria, the BEERS criteria to avoid in cognitively impaired patients (BEERS dementia PIM), the EU(7)-PIM and the PRISCUS list.of 2,865 participants, 261 were frail at baseline and 423 became frail during follow-up. Only BEERS dementia PIM use was statistically significantly associated with prevalent frailty (odds ratio (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31732737
%R 10.1093/ageing/afz127
%U https://inrepo02.dkfz.de/record/147646