TY  - JOUR
AU  - Laetsch, Dana Clarissa
AU  - Hoppe, Liesa Katharina
AU  - Saum, Kai-Uwe
AU  - Haefeli, Walter E
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Investigation of a possible association of potentially inappropriate medication for older adults and frailty in a prospective cohort study from Germany.
JO  - Age & ageing
VL  - 49
IS  - 1
SN  - 1468-2834
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2019-02637
SP  - 20-25
PY  - 2019
N1  - 2019 Dec 1;49(1):20-25
AB  - potentially inappropriate medications (PIMs) are commonly defined as drugs that should be avoided in older adults because they are considered to have a negative risk-benefit ratio. PIMs are suspected to increase the risk for frailty, but this has yet to be examined.prospective population-based cohort study.a German cohort of community-dwelling older adults (≥60 years) was followed from October 2008 to September 2016.in propensity score-adjusted logistic and Cox regression models, associations between baseline PIM use and prevalent/incident frailty were investigated. Frailty was assessed using the definition by Fried and co-workers, PIM were defined with the 2015 BEERS criteria, the BEERS criteria to avoid in cognitively impaired patients (BEERS dementia PIM), the EU(7)-PIM and the PRISCUS list.of 2,865 participants, 261 were frail at baseline and 423 became frail during follow-up. Only BEERS dementia PIM use was statistically significantly associated with prevalent frailty (odds ratio (95
LB  - PUB:(DE-HGF)16
C6  - pmid:31732737
DO  - DOI:10.1093/ageing/afz127
UR  - https://inrepo02.dkfz.de/record/147646
ER  -