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@ARTICLE{Laetsch:147646,
      author       = {D. C. Laetsch$^*$ and L. K. Hoppe and K.-U. Saum and W. E.
                      Haefeli and H. Brenner$^*$ and B. Schöttker$^*$},
      title        = {{I}nvestigation of a possible association of potentially
                      inappropriate medication for older adults and frailty in a
                      prospective cohort study from {G}ermany.},
      journal      = {Age $\&$ ageing},
      volume       = {49},
      number       = {1},
      issn         = {1468-2834},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2019-02637},
      pages        = {20-25},
      year         = {2019},
      note         = {2019 Dec 1;49(1):20-25},
      abstract     = {potentially inappropriate medications (PIMs) are commonly
                      defined as drugs that should be avoided in older adults
                      because they are considered to have a negative risk-benefit
                      ratio. PIMs are suspected to increase the risk for frailty,
                      but this has yet to be examined.prospective population-based
                      cohort study.a German cohort of community-dwelling older
                      adults (≥60 years) was followed from October 2008 to
                      September 2016.in propensity score-adjusted logistic and Cox
                      regression models, associations between baseline PIM use and
                      prevalent/incident frailty were investigated. Frailty was
                      assessed using the definition by Fried and co-workers, PIM
                      were defined with the 2015 BEERS criteria, the BEERS
                      criteria to avoid in cognitively impaired patients (BEERS
                      dementia PIM), the EU(7)-PIM and the PRISCUS list.of 2,865
                      participants, 261 were frail at baseline and 423 became
                      frail during follow-up. Only BEERS dementia PIM use was
                      statistically significantly associated with prevalent
                      frailty (odds ratio $(95\%$ confidence interval), 1.51
                      (1.04-2.17)). The strength of the association was comparable
                      for all frailty components. Similarly, in longitudinal
                      analyses, only BEERS dementia PIM use was associated with
                      incident frailty albeit not statistically significant
                      (hazard ratio, 1.19 (0.84-1.68)).the association of PIM use
                      and frailty seems to be restricted to drug classes, which
                      can induce frailty symptoms (anticholinergics,
                      benzodiazepines, z-substances and antipsychotics).
                      Physicians are advised to perform frailty assessments before
                      and after prescribing these drug classes to older patients
                      and to reconsider treatment decisions in case of negative
                      performance changes.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31732737},
      doi          = {10.1093/ageing/afz127},
      url          = {https://inrepo02.dkfz.de/record/147646},
}