TY  - JOUR
AU  - Adam, Salome
AU  - Doege, Daniela
AU  - Koch-Gallenkamp, Lena
AU  - Thong, Melissa S Y
AU  - Bertram, Heike
AU  - Eberle, Andrea
AU  - Holleczek, Bernd
AU  - Pritzkuleit, Ron
AU  - Waldeyer-Sauerland, Mechthild
AU  - Waldmann, Annika
AU  - Zeissig, Sylke Ruth
AU  - Jansen, Lina
AU  - Rohrmann, Sabine
AU  - Brenner, Hermann
AU  - Arndt, Volker
TI  - Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls-results from a population-based study.
JO  - Supportive care in cancer
VL  - 28
IS  - 6
SN  - 1433-7339
CY  - New York,NY
PB  - Springer
M1  - DKFZ-2019-02653
SP  - 2875-2885
PY  - 2020
N1  - 2020 Jun;28(6):2875-2885.#EA:C071#LA:C071#
AB  - Prostate cancer (PC) and its treatment may affect PC survivors differently with respect to age. However, little is known regarding age-specific health-related quality of life (HRQoL) in PC survivors 5 years or even ≥ 10 years post-diagnosis.The sample included 1975 disease-free PC survivors (5-16 years post-diagnosis) and 661 cancer-free population controls, recruited from two German population-based studies (CAESAR+, LinDe). HRQoL in both populations was assessed using the EORTC QLQ-C30 questionnaire. Additionally, PC survivors completed the PC-specific EORTC QLQ-PR25 questionnaire. Differences in HRQoL between survivors and controls, as well as differences according to age and time since diagnosis were analyzed with multiple regression after adjustment for age, education, stage, and time since diagnosis, where appropriate.In general, PC survivors reported HRQoL and symptom-burden levels comparable to the general population, except for significantly poorer social functioning and higher burden for diarrhea and constipation. In age-specific analyses, PC survivors up to 69 years indicated poorer global health and social functioning than population controls. Stratification by time since diagnosis revealed little difference between the subgroups. On PC-specific symptoms, burden was highest for urinary bother and symptoms, and lowest for bowel symptoms. Younger age was associated with less urinary symptoms but higher urinary bother.Long-term disease-free PC survivors reported overall good HRQoL, but experienced persistent specific detriments. Our data suggest that these detriments do not improve substantially with increasing time since diagnosis. Targeted interventions are recommended to prevent PC-related and treatment-related symptoms becoming chronic and to enhance social functioning.
LB  - PUB:(DE-HGF)16
C6  - pmid:31736000
DO  - DOI:10.1007/s00520-019-05120-5
UR  - https://inrepo02.dkfz.de/record/147664
ER  -