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@ARTICLE{Adam:147664,
      author       = {S. Adam$^*$ and D. Doege and L. Koch-Gallenkamp$^*$ and M.
                      S. Y. Thong and H. Bertram and A. Eberle and B. Holleczek
                      and R. Pritzkuleit and M. Waldeyer-Sauerland and A. Waldmann
                      and S. R. Zeissig and L. Jansen$^*$ and S. Rohrmann and H.
                      Brenner$^*$ and V. Arndt$^*$},
      title        = {{A}ge-specific health-related quality of life in
                      disease-free long-term prostate cancer survivors versus male
                      population controls-results from a population-based study.},
      journal      = {Supportive care in cancer},
      volume       = {28},
      number       = {6},
      issn         = {1433-7339},
      address      = {New York,NY},
      publisher    = {Springer},
      reportid     = {DKFZ-2019-02653},
      pages        = {2875-2885},
      year         = {2020},
      note         = {2020 Jun;28(6):2875-2885.#EA:C071#LA:C071#},
      abstract     = {Prostate cancer (PC) and its treatment may affect PC
                      survivors differently with respect to age. However, little
                      is known regarding age-specific health-related quality of
                      life (HRQoL) in PC survivors 5 years or even ≥ 10 years
                      post-diagnosis.The sample included 1975 disease-free PC
                      survivors (5-16 years post-diagnosis) and 661 cancer-free
                      population controls, recruited from two German
                      population-based studies (CAESAR+, LinDe). HRQoL in both
                      populations was assessed using the EORTC QLQ-C30
                      questionnaire. Additionally, PC survivors completed the
                      PC-specific EORTC QLQ-PR25 questionnaire. Differences in
                      HRQoL between survivors and controls, as well as differences
                      according to age and time since diagnosis were analyzed with
                      multiple regression after adjustment for age, education,
                      stage, and time since diagnosis, where appropriate.In
                      general, PC survivors reported HRQoL and symptom-burden
                      levels comparable to the general population, except for
                      significantly poorer social functioning and higher burden
                      for diarrhea and constipation. In age-specific analyses, PC
                      survivors up to 69 years indicated poorer global health and
                      social functioning than population controls. Stratification
                      by time since diagnosis revealed little difference between
                      the subgroups. On PC-specific symptoms, burden was highest
                      for urinary bother and symptoms, and lowest for bowel
                      symptoms. Younger age was associated with less urinary
                      symptoms but higher urinary bother.Long-term disease-free PC
                      survivors reported overall good HRQoL, but experienced
                      persistent specific detriments. Our data suggest that these
                      detriments do not improve substantially with increasing time
                      since diagnosis. Targeted interventions are recommended to
                      prevent PC-related and treatment-related symptoms becoming
                      chronic and to enhance social functioning.},
      cin          = {C071 / C070 / HD01 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C071-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31736000},
      doi          = {10.1007/s00520-019-05120-5},
      url          = {https://inrepo02.dkfz.de/record/147664},
}