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@ARTICLE{Beyerle:147669,
      author       = {J. Beyerle$^*$ and A. N. Holowatyj and M. Haffa$^*$ and E.
                      Frei$^*$ and B. Gigic and P. Schrotz-King$^*$ and J. Böhm
                      and N. Habermann and M. Stiborova and D. Scherer and T.
                      Koelsch and S. Skender$^*$ and N. Becker$^*$ and E. Herpel
                      and M. Schneider and A. Ulrich and P. Schirmacher and J.
                      Chang-Claude$^*$ and H. Brenner$^*$ and M. Hoffmeister$^*$
                      and U. Haug and R. W. Owen$^*$ and C. M. Ulrich},
      title        = {{E}xpression patterns of xenobiotic metabolizing enzymes in
                      tumor and adjacent normal mucosa tissues among patients with
                      colorectal cancer: {T}he {C}olo{C}are {S}tudy.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {29},
      number       = {2},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2019-02658},
      pages        = {460-469},
      year         = {2020},
      note         = {2020 Feb;29(2):460-469#EA:C120#},
      abstract     = {Xenobiotic metabolizing enzymes (XMEs) play a critical role
                      in the activation and detoxification of several carcinogens.
                      However, the role of XMEs in colorectal carcinogenesis is
                      unclear.We investigated the expression of XMEs in human
                      colorectal tissues among n=71 stage I-IV colorectal cancer
                      (CRC) patients from the ColoCare Study. Transcriptomic
                      profiling using paired colorectal tumor and adjacent normal
                      mucosa tissues of XMEs
                      (GSTM1,GSTA1,UGT1A8,UGT1A10,CYP3A4,CYP2C9,GSTP1,CYP2W1) by
                      RNA microarray was compared using Wilcoxon rank-sum tests.
                      We assessed associations between clinicopathologic, dietary,
                      and lifestyle-related factors and XME expression with linear
                      regression models.GSTM1, GSTA1, UGT1A8, UGT1A10, CYP3A4 were
                      all statistically significantly downregulated in colorectal
                      tumor relative to normal mucosa tissues (all p≤0.03).
                      Women had significantly higher expression of GSTM1 in normal
                      tissues compared to men (β=0.37,p-value=0.02). By tumor
                      site, CYP2C9 expression was lower in normal mucosa among
                      rectal cancer patients versus colon cancer cases
                      (β=-0.21,p-value=0.0005). Smokers demonstrated higher
                      CYP2C9 expression levels in normal mucosa (β=0.17,p=0.02)
                      when compared with non-smokers. Individuals who used NSAIDs
                      had higher GSTP1 tumor expression compared to non-NSAID
                      users (β=0.17,p=0.03). Higher consumption of cooked
                      vegetables (>1x/week) was associated with higher CYP3A4
                      expression in colorectal tumor tissues
                      (β=0.14,p=0.007).XMEs have lower expression in colorectal
                      tumor relative to normal mucosa tissues and may modify
                      colorectal carcinogenesis via associations with clinical,
                      lifestyle- and dietary-related factors.Better understanding
                      into the role of drug-metabolizing enzymes in CRC may reveal
                      biological differences that contribute to cancer development
                      as well as treatment response, leading to clinical
                      implications in CRC prevention and management.},
      cin          = {C120 / C020 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31740522},
      doi          = {10.1158/1055-9965.EPI-19-0449},
      url          = {https://inrepo02.dkfz.de/record/147669},
}