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| Home > Publications database > Expression patterns of xenobiotic metabolizing enzymes in tumor and adjacent normal mucosa tissues among patients with colorectal cancer: The ColoCare Study. > print |
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| 005 | 20240229123026.0 | ||
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| 100 | 1 | _ | |a Beyerle, Jolantha |0 P:(DE-He78)a286621712d6d390c909e519145368d0 |b 0 |e First author |
| 245 | _ | _ | |a Expression patterns of xenobiotic metabolizing enzymes in tumor and adjacent normal mucosa tissues among patients with colorectal cancer: The ColoCare Study. |
| 260 | _ | _ | |a Philadelphia, Pa. |c 2020 |b AACR |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a 2020 Feb;29(2):460-469#EA:C120# |
| 520 | _ | _ | |a Xenobiotic metabolizing enzymes (XMEs) play a critical role in the activation and detoxification of several carcinogens. However, the role of XMEs in colorectal carcinogenesis is unclear.We investigated the expression of XMEs in human colorectal tissues among n=71 stage I-IV colorectal cancer (CRC) patients from the ColoCare Study. Transcriptomic profiling using paired colorectal tumor and adjacent normal mucosa tissues of XMEs (GSTM1,GSTA1,UGT1A8,UGT1A10,CYP3A4,CYP2C9,GSTP1,CYP2W1) by RNA microarray was compared using Wilcoxon rank-sum tests. We assessed associations between clinicopathologic, dietary, and lifestyle-related factors and XME expression with linear regression models.GSTM1, GSTA1, UGT1A8, UGT1A10, CYP3A4 were all statistically significantly downregulated in colorectal tumor relative to normal mucosa tissues (all p≤0.03). Women had significantly higher expression of GSTM1 in normal tissues compared to men (β=0.37,p-value=0.02). By tumor site, CYP2C9 expression was lower in normal mucosa among rectal cancer patients versus colon cancer cases (β=-0.21,p-value=0.0005). Smokers demonstrated higher CYP2C9 expression levels in normal mucosa (β=0.17,p=0.02) when compared with non-smokers. Individuals who used NSAIDs had higher GSTP1 tumor expression compared to non-NSAID users (β=0.17,p=0.03). Higher consumption of cooked vegetables (>1x/week) was associated with higher CYP3A4 expression in colorectal tumor tissues (β=0.14,p=0.007).XMEs have lower expression in colorectal tumor relative to normal mucosa tissues and may modify colorectal carcinogenesis via associations with clinical, lifestyle- and dietary-related factors.Better understanding into the role of drug-metabolizing enzymes in CRC may reveal biological differences that contribute to cancer development as well as treatment response, leading to clinical implications in CRC prevention and management. |
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| 700 | 1 | _ | |a Frei, Eva |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Gigic, Biljana |b 4 |
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| 700 | 1 | _ | |a Böhm, Jürgen |b 6 |
| 700 | 1 | _ | |a Habermann, Nina |b 7 |
| 700 | 1 | _ | |a Stiborova, Marie |0 0000-0001-5430-4403 |b 8 |
| 700 | 1 | _ | |a Scherer, Dominique |b 9 |
| 700 | 1 | _ | |a Koelsch, Torsten |b 10 |
| 700 | 1 | _ | |a Skender, Stephanie |0 P:(DE-HGF)0 |b 11 |
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| 700 | 1 | _ | |a Herpel, Esther |b 13 |
| 700 | 1 | _ | |a Schneider, Martin |b 14 |
| 700 | 1 | _ | |a Ulrich, Alexis |b 15 |
| 700 | 1 | _ | |a Schirmacher, Peter |b 16 |
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| 700 | 1 | _ | |a Haug, Ulrike |b 20 |
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| 700 | 1 | _ | |a Ulrich, Cornelia M |b 22 |
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