TY  - JOUR
AU  - Brenner, Hermann
AU  - Gies, Anton
AU  - Selby, Kevin
TI  - Overestimated Sensitivity of Fecal Immunochemical Tests in Screening Cohorts With Registry-Based Follow-up.
JO  - The American journal of gastroenterology
VL  - 114
IS  - 11
SN  - 0002-9270
CY  - London [u.a.]
PB  - Nature
M1  - DKFZ-2019-02674
SP  - 1795 - 1801
PY  - 2019
AB  - Several recent studies have reported very high estimates of sensitivity and specificity of fecal immunochemical tests (FITs) at seemingly high levels of precision using registry-based follow-up of participants in very large FIT-based screening programs. We aimed to assess the validity of estimates of diagnostic performance parameters derived by this indirect approach.We modeled expected values of sensitivity and specificity of colorectal cancer detection in studies using the indirect approach and their deviation from true values under a broad range of plausible assumptions, and we compared these expected values with recently reported estimates of FIT sensitivity and specificity from such studies.Using a sensitivity of 75
LB  - PUB:(DE-HGF)16
C6  - pmid:31658130
DO  - DOI:10.14309/ajg.0000000000000412
UR  - https://inrepo02.dkfz.de/record/147686
ER  -