000147697 001__ 147697 000147697 005__ 20240229123028.0 000147697 0247_ $$2doi$$a10.1093/ije/dyz099 000147697 0247_ $$2pmid$$apmid:31321439 000147697 0247_ $$2ISSN$$a0300-5771 000147697 0247_ $$2ISSN$$a1464-3685 000147697 0247_ $$2altmetric$$aaltmetric:63804361 000147697 037__ $$aDKFZ-2019-02679 000147697 041__ $$aeng 000147697 082__ $$a610 000147697 1001_ $$aNCD Risk Factor Collaboration$$b0$$eCollaboration Author 000147697 245__ $$aNational trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries. 000147697 260__ $$aOxford$$bOxford Univ. Press$$c2020 000147697 3367_ $$2DRIVER$$aarticle 000147697 3367_ $$2DataCite$$aOutput Types/Journal article 000147697 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1597221636_3511 000147697 3367_ $$2BibTeX$$aARTICLE 000147697 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000147697 3367_ $$00$$2EndNote$$aJournal Article 000147697 500__ $$a2020 Feb 1;49(1):173-192 000147697 520__ $$aAlthough high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries.We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group.Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China.HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol. 000147697 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0 000147697 588__ $$aDataset connected to CrossRef, PubMed, 000147697 7001_ $$aTaddei, Cristina$$b1 000147697 7001_ $$aJackson, Rod$$b2 000147697 7001_ $$aZhou, Bin$$b3 000147697 7001_ $$aBixby, Honor$$b4 000147697 7001_ $$aDanaei, Goodarz$$b5 000147697 7001_ $$aDi Cesare, Mariachiara$$b6 000147697 7001_ $$aKuulasmaa, Kari$$b7 000147697 7001_ $$aHajifathalian, Kaveh$$b8 000147697 7001_ $$aBentham, James$$b9 000147697 7001_ $$aBennett, James E$$b10 000147697 7001_ $$aAekplakorn, Wichai$$b11 000147697 7001_ $$aCifkova, Renata$$b12 000147697 7001_ $$aDallongeville, Jean$$b13 000147697 7001_ $$aDeBacquer, Dirk$$b14 000147697 7001_ $$aGiampaoli, 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7001_ $$aLappas, Georg$$b206 000147697 7001_ $$aLaugsand, LarsE$$b207 000147697 7001_ $$aLee, Jeonghee$$b208 000147697 7001_ $$aLehtimäki, Terho$$b209 000147697 7001_ $$aLi, Yanping$$b210 000147697 7001_ $$aLilly, ChristaL$$b211 000147697 7001_ $$aLin, Xu$$b212 000147697 7001_ $$aLind, Lars$$b213 000147697 7001_ $$aLissner, Lauren$$b214 000147697 7001_ $$aLiu, Jing$$b215 000147697 7001_ $$aLopez-Garcia, Esther$$b216 000147697 7001_ $$aLorbeer, Roberto$$b217 000147697 7001_ $$aEugenioLozano, José$$b218 000147697 7001_ $$aLuksiene, Dalia$$b219 000147697 7001_ $$aLundqvist, Annamari$$b220 000147697 7001_ $$aLundqvist, Robert$$b221 000147697 7001_ $$aLytsy, Per$$b222 000147697 7001_ $$aMa, Guansheng$$b223 000147697 7001_ $$aMachi, Suka$$b224 000147697 7001_ $$aMaggi, Stefania$$b225 000147697 7001_ $$aMagliano, DiannaJ$$b226 000147697 7001_ $$aMann, JimI$$b227 000147697 7001_ $$aManzato, Enzo$$b228 000147697 7001_ $$aMarques-Vidal, Pedro$$b229 000147697 7001_ $$aMathiesen, EllisivB$$b230 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