%0 Journal Article
%A Hoppe, Liesa
%A Muhlack, Dana Clarissa
%A Koenig, Wolfgang
%A Brenner, Hermann
%A Schöttker, Ben
%T The Associations of Diuretics and Laxatives Use with Cardiovascular Mortality. An Individual Patient-Data Meta-analysis of Two Large Cohort Studies.
%J Cardiovascular drugs and therapy
%V 33
%N 5
%@ 1573-7241
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V
%M DKFZ-2019-02680
%P 567-579
%D 2019
%Z 2019 Oct;33(5):567-579
%X To investigate the associations of diuretics overall, non-potassium-sparing diuretics in specific, and laxative use with cardiovascular mortality (CVM) in subjects with antihypertensive treatment.Analyses included 4253 participants, aged 50 to 75 years, from the German ESTHER cohort and 105,359 participants, aged 50 to 69 years, from the UK Biobank. Cox proportional hazard regression models were applied in both studies, and then results were pooled using random-effects model meta-analyses.During 14 and 7 years of follow-up, 476 and 1616 CVM cases were observed in the ESTHER study and the UK Biobank, respectively. Compared to non-users, a 1.6-fold (hazard ratio [95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31375970
%R 10.1007/s10557-019-06894-w
%U https://inrepo02.dkfz.de/record/147698