000147775 001__ 147775 000147775 005__ 20240229112657.0 000147775 0247_ $$2doi$$a10.1038/s41571-019-0177-5 000147775 0247_ $$2pmid$$apmid:30733593 000147775 0247_ $$2pmc$$apmc:PMC6650350 000147775 0247_ $$2ISSN$$a1743-4254 000147775 0247_ $$2ISSN$$a1743-4262 000147775 0247_ $$2ISSN$$a1759-4774 000147775 0247_ $$2ISSN$$a1759-4782 000147775 0247_ $$2altmetric$$aaltmetric:55076290 000147775 037__ $$aDKFZ-2019-02749 000147775 041__ $$aeng 000147775 082__ $$a610 000147775 1001_ $$0P:(DE-HGF)0$$aAldape, Kenneth$$b0 000147775 245__ $$aChallenges to curing primary brain tumours. 000147775 260__ $$aNew York, NY$$bNature Publ. Group$$c2019 000147775 3367_ $$2DRIVER$$aarticle 000147775 3367_ $$2DataCite$$aOutput Types/Journal article 000147775 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1575276202_24216 000147775 3367_ $$2BibTeX$$aARTICLE 000147775 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000147775 3367_ $$00$$2EndNote$$aJournal Article 000147775 520__ $$aDespite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment. 000147775 536__ $$0G:(DE-HGF)POF3-312$$a312 - Functional and structural genomics (POF3-312)$$cPOF3-312$$fPOF III$$x0 000147775 588__ $$aDataset connected to CrossRef, PubMed, 000147775 7001_ $$0P:(DE-HGF)0$$aBrindle, Kevin M$$b1 000147775 7001_ $$0P:(DE-HGF)0$$aChesler, Louis$$b2 000147775 7001_ $$0P:(DE-HGF)0$$aChopra, Rajesh$$b3 000147775 7001_ $$0P:(DE-HGF)0$$aGajjar, Amar$$b4 000147775 7001_ $$0P:(DE-HGF)0$$aGilbert, Mark R$$b5 000147775 7001_ $$0P:(DE-HGF)0$$aGottardo, Nicholas$$b6 000147775 7001_ $$0P:(DE-HGF)0$$aGutmann, David H$$b7 000147775 7001_ $$0P:(DE-HGF)0$$aHargrave, Darren$$b8 000147775 7001_ $$0P:(DE-HGF)0$$aHolland, Eric C$$b9 000147775 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David T W$$b10$$udkfz 000147775 7001_ $$0P:(DE-HGF)0$$aJoyce, Johanna A$$b11 000147775 7001_ $$0P:(DE-HGF)0$$aKearns, Pamela$$b12 000147775 7001_ $$0P:(DE-HGF)0$$aKieran, Mark W$$b13 000147775 7001_ $$0P:(DE-HGF)0$$aMellinghoff, Ingo K$$b14 000147775 7001_ $$0P:(DE-HGF)0$$aMerchant, Melinda$$b15 000147775 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b16$$udkfz 000147775 7001_ $$0P:(DE-HGF)0$$aPollard, Steven M$$b17 000147775 7001_ $$00000-0002-6557-895X$$aRamaswamy, Vijay$$b18 000147775 7001_ $$0P:(DE-HGF)0$$aRich, Jeremy N$$b19 000147775 7001_ $$00000-0001-7441-9486$$aRobinson, Giles W$$b20 000147775 7001_ $$0P:(DE-HGF)0$$aRowitch, David H$$b21 000147775 7001_ $$0P:(DE-HGF)0$$aSampson, John H$$b22 000147775 7001_ $$0P:(DE-HGF)0$$aTaylor, Michael D$$b23 000147775 7001_ $$0P:(DE-HGF)0$$aWorkman, Paul$$b24 000147775 7001_ $$00000-0001-7539-9472$$aGilbertson, Richard J$$b25 000147775 773__ $$0PERI:(DE-600)2491414-9$$a10.1038/s41571-019-0177-5$$gVol. 16, no. 8, p. 509 - 520$$n8$$p509 - 520$$tNature reviews / Clinical oncology Clinical oncology [...]$$v16$$x1759-4782$$y2019 000147775 909CO $$ooai:inrepo02.dkfz.de:147775$$pVDB 000147775 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)551bb92841f634070997aa168d818492$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ 000147775 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aDeutsches Krebsforschungszentrum$$b16$$kDKFZ 000147775 9131_ $$0G:(DE-HGF)POF3-312$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vFunctional and structural genomics$$x0 000147775 9141_ $$y2019 000147775 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz 000147775 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS 000147775 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline 000147775 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT REV CLIN ONCOL : 2017 000147775 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List 000147775 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index 000147775 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection 000147775 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded 000147775 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine 000147775 915__ $$0StatID:(DE-HGF)9920$$2StatID$$aIF >= 20$$bNAT REV CLIN ONCOL : 2017 000147775 9201_ $$0I:(DE-He78)B360-20160331$$kB360$$lPediatric Glioma$$x0 000147775 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lPädiatrische Neuroonkologie$$x1 000147775 980__ $$ajournal 000147775 980__ $$aVDB 000147775 980__ $$aI:(DE-He78)B360-20160331 000147775 980__ $$aI:(DE-He78)B062-20160331 000147775 980__ $$aUNRESTRICTED