TY  - JOUR
AU  - Aldape, Kenneth
AU  - Brindle, Kevin M
AU  - Chesler, Louis
AU  - Chopra, Rajesh
AU  - Gajjar, Amar
AU  - Gilbert, Mark R
AU  - Gottardo, Nicholas
AU  - Gutmann, David H
AU  - Hargrave, Darren
AU  - Holland, Eric C
AU  - Jones, David T W
AU  - Joyce, Johanna A
AU  - Kearns, Pamela
AU  - Kieran, Mark W
AU  - Mellinghoff, Ingo K
AU  - Merchant, Melinda
AU  - Pfister, Stefan M
AU  - Pollard, Steven M
AU  - Ramaswamy, Vijay
AU  - Rich, Jeremy N
AU  - Robinson, Giles W
AU  - Rowitch, David H
AU  - Sampson, John H
AU  - Taylor, Michael D
AU  - Workman, Paul
AU  - Gilbertson, Richard J
TI  - Challenges to curing primary brain tumours.
JO  - Nature reviews / Clinical oncology Clinical oncology [...]
VL  - 16
IS  - 8
SN  - 1759-4782
CY  - New York, NY
PB  - Nature Publ. Group
M1  - DKFZ-2019-02749
SP  - 509 - 520
PY  - 2019
AB  - Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.
LB  - PUB:(DE-HGF)16
C6  - pmid:30733593
C2  - pmc:PMC6650350
DO  - DOI:10.1038/s41571-019-0177-5
UR  - https://inrepo02.dkfz.de/record/147775
ER  -