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@ARTICLE{Aldape:147775,
      author       = {K. Aldape and K. M. Brindle and L. Chesler and R. Chopra
                      and A. Gajjar and M. R. Gilbert and N. Gottardo and D. H.
                      Gutmann and D. Hargrave and E. C. Holland and D. T. W.
                      Jones$^*$ and J. A. Joyce and P. Kearns and M. W. Kieran and
                      I. K. Mellinghoff and M. Merchant and S. M. Pfister$^*$ and
                      S. M. Pollard and V. Ramaswamy and J. N. Rich and G. W.
                      Robinson and D. H. Rowitch and J. H. Sampson and M. D.
                      Taylor and P. Workman and R. J. Gilbertson},
      title        = {{C}hallenges to curing primary brain tumours.},
      journal      = {Nature reviews / Clinical oncology Clinical oncology [...]},
      volume       = {16},
      number       = {8},
      issn         = {1759-4782},
      address      = {New York, NY},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2019-02749},
      pages        = {509 - 520},
      year         = {2019},
      abstract     = {Despite decades of research, brain tumours remain among the
                      deadliest of all forms of cancer. The ability of these
                      tumours to resist almost all conventional and novel
                      treatments relates, in part, to the unique cell-intrinsic
                      and microenvironmental properties of neural tissues. In an
                      attempt to encourage progress in our understanding and
                      ability to successfully treat patients with brain tumours,
                      Cancer Research UK convened an international panel of
                      clinicians and laboratory-based scientists to identify
                      challenges that must be overcome if we are to cure all
                      patients with a brain tumour. The seven key challenges
                      summarized in this Position Paper are intended to serve as
                      foci for future research and investment.},
      cin          = {B360 / B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B360-20160331 / I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30733593},
      pmc          = {pmc:PMC6650350},
      doi          = {10.1038/s41571-019-0177-5},
      url          = {https://inrepo02.dkfz.de/record/147775},
}