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| Home > Publications database > RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction. > print |
| Home > Publications database > RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction. > print |
| 001 | 147918 | ||
| 005 | 20240229112658.0 | ||
| 024 | 7 | _ | |a 10.1016/j.celrep.2019.08.040 |2 doi |
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| 037 | _ | _ | |a DKFZ-2019-02779 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Ptasinska, Anetta |b 0 |
| 245 | _ | _ | |a RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction. |
| 260 | _ | _ | |a [New York, NY] |c 2019 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1575533325_24886 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The t(8;21)(q22;q22) translocation generates the RUNX1-ETO fusion protein, which interferes with the hematopoietic master regulator RUNX1. We previously showed that the maintenance of t(8;21) AML is dependent on RUNX1-ETO expression. Its depletion causes extensive changes in transcription factor binding, as well as gene expression, and initiates myeloid differentiation. However, how these processes are connected within a gene regulatory network is unclear. To address this question, we performed Promoter-Capture Hi-C assays, with or without RUNX1-ETO depletion and assigned interacting cis-regulatory elements to their respective genes. To construct a RUNX1-ETO-dependent gene regulatory network maintaining AML, we integrated cis-regulatory element interactions with gene expression and transcription factor binding data. This analysis shows that RUNX1-ETO participates in cis-regulatory element interactions. However, differential interactions following RUNX1-ETO depletion are driven by alterations in the binding of RUNX1-ETO-regulated transcription factors. |
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| 700 | 1 | _ | |a Pickin, Anna |b 1 |
| 700 | 1 | _ | |a Assi, Salam A |b 2 |
| 700 | 1 | _ | |a Chin, Paulynn Suyin |b 3 |
| 700 | 1 | _ | |a Ames, Luke |b 4 |
| 700 | 1 | _ | |a Avellino, Roberto |b 5 |
| 700 | 1 | _ | |a Gröschel, Stefan |0 P:(DE-He78)5120a331b1c28045c8ca6a8b1c73c95f |b 6 |u dkfz |
| 700 | 1 | _ | |a Delwel, Ruud |b 7 |
| 700 | 1 | _ | |a Cockerill, Peter N |b 8 |
| 700 | 1 | _ | |a Osborne, Cameron S |b 9 |
| 700 | 1 | _ | |a Bonifer, Constanze |0 P:(DE-HGF)0 |b 10 |
| 773 | _ | _ | |a 10.1016/j.celrep.2019.08.040 |g Vol. 28, no. 12, p. 3022 - 3031.e7 |0 PERI:(DE-600)2649101-1 |n 12 |p 3022 - 3031.e7 |t Cell reports |v 28 |y 2019 |x 2211-1247 |
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