%0 Journal Article
%A d'Errico, Margherita
%A Alwers, Elizabeth
%A Zhang, Yan
%A Edelmann, Dominic
%A Brenner, Hermann
%A Hoffmeister, Michael
%T Identification of prognostic DNA methylation biomarkers in patients with gastrointestinal adenocarcinomas: A systematic review of epigenome-wide studies.
%J Cancer treatment reviews
%V 82
%@ 0305-7372
%C Amsterdam [u.a.]
%I Elsevier
%M DKFZ-2019-02859
%P 101933
%D 2020
%Z 2020 Jan;82:101933#EA:C070#LA:C070#
%X This systematic review aims to summarize epigenome-wide studies on aberrant DNA methylation and its association with survival in patients with gastrointestinal adenocarcinoma. The 15 studies identified showed a large variety of methodological approaches for the identification of prognostic epigenetic markers from genome-wide methylation analyses. None of the findings were reported by more than one study in this systematic review. Further validation studies, a better reporting of methods and results are needed, as well as a clearer definition of investigated outcomes. At present, no conclusions can be drawn on the clinical relevance of the reported epigenetic markers.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31785412
%R 10.1016/j.ctrv.2019.101933
%U https://inrepo02.dkfz.de/record/148295