TY  - JOUR
AU  - d'Errico, Margherita
AU  - Alwers, Elizabeth
AU  - Zhang, Yan
AU  - Edelmann, Dominic
AU  - Brenner, Hermann
AU  - Hoffmeister, Michael
TI  - Identification of prognostic DNA methylation biomarkers in patients with gastrointestinal adenocarcinomas: A systematic review of epigenome-wide studies.
JO  - Cancer treatment reviews
VL  - 82
SN  - 0305-7372
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2019-02859
SP  - 101933
PY  - 2020
N1  - 2020 Jan;82:101933#EA:C070#LA:C070#
AB  - This systematic review aims to summarize epigenome-wide studies on aberrant DNA methylation and its association with survival in patients with gastrointestinal adenocarcinoma. The 15 studies identified showed a large variety of methodological approaches for the identification of prognostic epigenetic markers from genome-wide methylation analyses. None of the findings were reported by more than one study in this systematic review. Further validation studies, a better reporting of methods and results are needed, as well as a clearer definition of investigated outcomes. At present, no conclusions can be drawn on the clinical relevance of the reported epigenetic markers.
LB  - PUB:(DE-HGF)16
C6  - pmid:31785412
DO  - DOI:10.1016/j.ctrv.2019.101933
UR  - https://inrepo02.dkfz.de/record/148295
ER  -