Home > Publications database > Identification of prognostic DNA methylation biomarkers in patients with gastrointestinal adenocarcinomas: A systematic review of epigenome-wide studies. > print

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024 7 _ |a 10.1016/j.ctrv.2019.101933
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100 1 _ |a d'Errico, Margherita
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245 _ _ |a Identification of prognostic DNA methylation biomarkers in patients with gastrointestinal adenocarcinomas: A systematic review of epigenome-wide studies.
260 _ _ |a Amsterdam [u.a.]
|c 2020
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500 _ _ |a 2020 Jan;82:101933#EA:C070#LA:C070#
520 _ _ |a This systematic review aims to summarize epigenome-wide studies on aberrant DNA methylation and its association with survival in patients with gastrointestinal adenocarcinoma. The 15 studies identified showed a large variety of methodological approaches for the identification of prognostic epigenetic markers from genome-wide methylation analyses. None of the findings were reported by more than one study in this systematic review. Further validation studies, a better reporting of methods and results are needed, as well as a clearer definition of investigated outcomes. At present, no conclusions can be drawn on the clinical relevance of the reported epigenetic markers.
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700 1 _ |a Alwers, Elizabeth
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700 1 _ |a Zhang, Yan
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700 1 _ |a Edelmann, Dominic
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700 1 _ |a Brenner, Hermann
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700 1 _ |a Hoffmeister, Michael
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