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| 001 | 148300 | ||
| 005 | 20240229121831.0 | ||
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| 100 | 1 | _ | |a Pletsch-Borba, Laura |0 0000-0003-4872-6452 |b 0 |e First author |
| 245 | _ | _ | |a Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis. |
| 260 | _ | _ | |a Basel |c 2019 |b MDPI |
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| 520 | _ | _ | |a Data on biomarkers of vascular injury and type 2 diabetes (T2D) risk from prospective studies are lacking. We evaluated seven biomarkers of vascular injury in relation to T2D. Additionally, a meta-analysis was performed. From the EPIC-Heidelberg cohort, 2224 participants were followed-up from baseline for 16 (median) years. E-Selectin, P-Selectin, intercellular adhesion molecule 3 (ICAM3), thrombomodulin, thrombopoietin, glycoprotein IIb/IIIa and fibrinogen levels were measured in baseline blood samples. The systematic review and meta-analysis included prospective studies identified through MEDLINE and Web of Science that investigated the association between mentioned biomarkers and T2D. The study population included 55% women, median age was 50 years, and 163 developed T2D. ICAM3 was associated with lower T2D risk (fully adjusted HRhighest vs. lowest tertile 0.62 (95% CI: 0.43, 0.91)), but no other studies on ICAM3 were identified. Overall, fifteen studies were included in the systematic review and meta-analysis (6,171 cases). E-Selectin was associated with higher T2D risk HRper SD: 1.34 (95% CI: 1.16, 1.54; I2 = 63%, n = 9 studies), while thrombomodulin was associated with lower risk HRper SD: 0.82 (95% CI: 0.71, 0.95; I2 = 0%, n = 2 studies). In the EPIC-Heidelberg, ICAM3 was associated with lower T2D risk. The meta-analysis showed a consistent positive association between E-Selectin and T2D. It was also suggestive of an inverse association between thrombomodulin and T2D, although further studies are needed to corroborate this finding. |
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| 700 | 1 | _ | |a Groß, Marie-Luise |b 8 |
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| 700 | 1 | _ | |a Bugert, Peter |b 11 |
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| 773 | _ | _ | |a 10.3390/jcm8122075 |g Vol. 8, no. 12, p. 2075 - |0 PERI:(DE-600)2662592-1 |n 12 |p 2075 |t Journal of Clinical Medicine |v 8 |y 2019 |x 2077-0383 |
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