TY  - JOUR
AU  - Jones, David
AU  - Bandopadhayay, Pratiti
AU  - Jabado, Nada
TI  - The Power of Human Cancer Genetics as Revealed by Low-Grade Gliomas.
JO  - Annual review of genetics
VL  - 53
IS  - 1
SN  - 1545-2948
CY  - Palo Alto, Calif.
PB  - Annual Review
M1  - DKFZ-2019-02872
SP  - 483 - 503
PY  - 2019
N1  - EA: B360
AB  - The human brain contains a vast number of cells and shows extraordinary cellular diversity to facilitate the many cognitive and automatic commands governing our bodily functions. This complexity arises partly from large-scale structural variations in the genome, evolutionary processes to increase brain size, function, and cognition. Not surprisingly given recent technical advances, low-grade gliomas (LGGs), which arise from the glia (the most abundant cell type in the brain), have undergone a recent revolution in their classification and therapy, especially in the pediatric setting. Next-generation sequencing has uncovered previously unappreciated diverse LGG entities, unraveling genetic subgroups and multiple molecular alterations and altered pathways, including many amenable to therapeutic targeting. In this article we review these novel entities, in which oncogenic processes show striking age-related neuroanatomical specificity (highlighting their close interplay with development); the opportunities they provide for targeted therapies, some of which are already practiced at the bedside; and the challenges of implementing molecular pathology in the clinic.
LB  - PUB:(DE-HGF)16
C6  - pmid:31794268
DO  - DOI:10.1146/annurev-genet-120417-031642
UR  - https://inrepo02.dkfz.de/record/148314
ER  -