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@ARTICLE{Jones:148314,
      author       = {D. Jones$^*$ and P. Bandopadhayay and N. Jabado},
      title        = {{T}he {P}ower of {H}uman {C}ancer {G}enetics as {R}evealed
                      by {L}ow-{G}rade {G}liomas.},
      journal      = {Annual review of genetics},
      volume       = {53},
      number       = {1},
      issn         = {1545-2948},
      address      = {Palo Alto, Calif.},
      publisher    = {Annual Review},
      reportid     = {DKFZ-2019-02872},
      pages        = {483 - 503},
      year         = {2019},
      note         = {EA: B360},
      abstract     = {The human brain contains a vast number of cells and shows
                      extraordinary cellular diversity to facilitate the many
                      cognitive and automatic commands governing our bodily
                      functions. This complexity arises partly from large-scale
                      structural variations in the genome, evolutionary processes
                      to increase brain size, function, and cognition. Not
                      surprisingly given recent technical advances, low-grade
                      gliomas (LGGs), which arise from the glia (the most abundant
                      cell type in the brain), have undergone a recent revolution
                      in their classification and therapy, especially in the
                      pediatric setting. Next-generation sequencing has uncovered
                      previously unappreciated diverse LGG entities, unraveling
                      genetic subgroups and multiple molecular alterations and
                      altered pathways, including many amenable to therapeutic
                      targeting. In this article we review these novel entities,
                      in which oncogenic processes show striking age-related
                      neuroanatomical specificity (highlighting their close
                      interplay with development); the opportunities they provide
                      for targeted therapies, some of which are already practiced
                      at the bedside; and the challenges of implementing molecular
                      pathology in the clinic.},
      subtyp        = {Review Article},
      cin          = {B360},
      ddc          = {570},
      cid          = {I:(DE-He78)B360-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31794268},
      doi          = {10.1146/annurev-genet-120417-031642},
      url          = {https://inrepo02.dkfz.de/record/148314},
}