TY  - JOUR
AU  - Tahiri, Iasim
AU  - Garro-Aguilar, Yaiza
AU  - Cayssials, Valerie
AU  - Achaintre, David
AU  - Mancini, Francesca Romana
AU  - Mahamat-Saleh, Yahya
AU  - Boutron-Ruault, Marie-Christine
AU  - Kühn, Tilman
AU  - Katzke, Verena
AU  - Boeing, Heiner
AU  - Trichopoulou, Antonia
AU  - Karakatsani, Anna
AU  - Valanou, Elisavet
AU  - Palli, Domenico
AU  - Sieri, Sabina
AU  - Santucci de Magistris, Maria
AU  - Tumino, Rosario
AU  - Macciotta, Alessandra
AU  - Huybrechts, Inge
AU  - Agudo, Antonio
AU  - Scalbert, Augustin
AU  - Zamora-Ros, Raul
TI  - Urinary flavanone concentrations as biomarkers of dietary flavanone intakes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
JO  - British journal of nutrition
VL  - 123
IS  - 6
SN  - 1475-2662
CY  - Cambridge
PB  - Cambridge Univ. Press
M1  - DKFZ-2019-02874
SP  - 691-698
PY  - 2020
N1  - 2020 Mar 28;123(6):691-698
AB  - In this study, the aim was to investigate the correlation between the acute and habitual dietary intake of flavanones, and their main food sources, and the concentrations of aglycones naringenin and hesperetin in 24h urine in a European population. A 24-h dietary recall (24-HDR) and a 24-h urine sample were collected the same day from a subsample of 475 people from 4 different countries of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Acute and habitual dietary data were captured through a standardized 24-HDR and a country/centre-specific validated dietary questionnaire. The intake of dietary flavanones was estimated using the Phenol-Explorer database. Urinary flavanones (naringenin and hesperetin) were analysed using tandem mass spectrometry with a previous enzymatic hydrolysis. Weak partial correlation coefficients were found between urinary flavanone concentrations and both acute and habitual dietary flavanone intakes (Rpartial=0.14-0.17). Partial correlations were stronger between urinary excretions and acute intakes of citrus fruit and juices (Rpartial 0.6) than with habitual intakes of citrus fruit and juices (Rpartial 0.24). In conclusion, according to our results urinary excretion of flavanones can be considered good biomarkers of acute citrus intake. However, low associations between habitual flavanone intake and urinary excretion suggest a possible inaccurate estimation of their intake or a too sporadic intake. For assessing habitual exposures, multiple urinary collections may be needed. These results show that none of the approaches tested is ideal, and the use of both dietary questionnaires and biomarkers can be recommended.
LB  - PUB:(DE-HGF)16
C6  - pmid:31791423
DO  - DOI:10.1017/S0007114519003131
UR  - https://inrepo02.dkfz.de/record/148316
ER  -