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@ARTICLE{Tahiri:148316,
      author       = {I. Tahiri and Y. Garro-Aguilar and V. Cayssials and D.
                      Achaintre and F. R. Mancini and Y. Mahamat-Saleh and M.-C.
                      Boutron-Ruault and T. Kühn$^*$ and V. Katzke$^*$ and H.
                      Boeing and A. Trichopoulou and A. Karakatsani and E. Valanou
                      and D. Palli and S. Sieri and M. Santucci de Magistris and
                      R. Tumino and A. Macciotta and I. Huybrechts and A. Agudo
                      and A. Scalbert and R. Zamora-Ros},
      title        = {{U}rinary flavanone concentrations as biomarkers of dietary
                      flavanone intakes in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition ({EPIC})
                      study.},
      journal      = {British journal of nutrition},
      volume       = {123},
      number       = {6},
      issn         = {1475-2662},
      address      = {Cambridge},
      publisher    = {Cambridge Univ. Press},
      reportid     = {DKFZ-2019-02874},
      pages        = {691-698},
      year         = {2020},
      note         = {2020 Mar 28;123(6):691-698},
      abstract     = {In this study, the aim was to investigate the correlation
                      between the acute and habitual dietary intake of flavanones,
                      and their main food sources, and the concentrations of
                      aglycones naringenin and hesperetin in 24h urine in a
                      European population. A 24-h dietary recall (24-HDR) and a
                      24-h urine sample were collected the same day from a
                      subsample of 475 people from 4 different countries of the
                      European Prospective Investigation into Cancer and Nutrition
                      (EPIC) study. Acute and habitual dietary data were captured
                      through a standardized 24-HDR and a country/centre-specific
                      validated dietary questionnaire. The intake of dietary
                      flavanones was estimated using the Phenol-Explorer database.
                      Urinary flavanones (naringenin and hesperetin) were analysed
                      using tandem mass spectrometry with a previous enzymatic
                      hydrolysis. Weak partial correlation coefficients were found
                      between urinary flavanone concentrations and both acute and
                      habitual dietary flavanone intakes (Rpartial=0.14-0.17).
                      Partial correlations were stronger between urinary
                      excretions and acute intakes of citrus fruit and juices
                      (Rpartial~0.6) than with habitual intakes of citrus fruit
                      and juices (Rpartial~0.24). In conclusion, according to our
                      results urinary excretion of flavanones can be considered
                      good biomarkers of acute citrus intake. However, low
                      associations between habitual flavanone intake and urinary
                      excretion suggest a possible inaccurate estimation of their
                      intake or a too sporadic intake. For assessing habitual
                      exposures, multiple urinary collections may be needed. These
                      results show that none of the approaches tested is ideal,
                      and the use of both dietary questionnaires and biomarkers
                      can be recommended.},
      cin          = {C020},
      ddc          = {570},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31791423},
      doi          = {10.1017/S0007114519003131},
      url          = {https://inrepo02.dkfz.de/record/148316},
}