000148317 001__ 148317
000148317 005__ 20240229123031.0
000148317 0247_ $$2doi$$a10.1007/s00432-019-03093-w
000148317 0247_ $$2pmid$$apmid:31768620
000148317 0247_ $$2ISSN$$a0084-5353
000148317 0247_ $$2ISSN$$a0171-5216
000148317 0247_ $$2ISSN$$a0943-9382
000148317 0247_ $$2ISSN$$a1432-1335
000148317 0247_ $$2altmetric$$aaltmetric:71239252
000148317 037__ $$aDKFZ-2019-02875
000148317 041__ $$aeng
000148317 082__ $$a610
000148317 1001_ $$aKommoss, Felix K F$$b0
000148317 245__ $$aDNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.213
000148317 260__ $$aBerlin$$bSpringer42162$$c2020
000148317 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2019-11-25
000148317 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2020-01-01
000148317 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2020-01-01
000148317 3367_ $$2DRIVER$$aarticle
000148317 3367_ $$2DataCite$$aOutput Types/Journal article
000148317 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1682429961_10670
000148317 3367_ $$2BibTeX$$aARTICLE
000148317 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000148317 3367_ $$00$$2EndNote$$aJournal Article
000148317 500__ $$a2020 Jan;146(1):97-104 / #LA:B300#
000148317 520__ $$aUterine neoplasms comprise a broad spectrum of lesions, some of which may pose a diagnostic challenge even to experienced pathologists. Recently, genome-wide DNA methylation-based classification of central nervous system tumors has been shown to increase diagnostic precision in clinical practice when combined with standard histopathology. In this study, we describe DNA methylation patterns of a diverse set of uterine neoplasms and test the applicability of array-based DNA methylation profiling.A multicenter cohort including prototypical epithelial and mesenchymal uterine neoplasms was collected. Tumors were subject to pathology review and array-based DNA methylation profiling (Illumina Infinium HumanMethylation450 or EPIC [850k] BeadChip). Methylation data were analyzed by unsupervised hierarchical clustering and t-SNE analysis.After sample retrieval and pathology review the study cohort consisted of 49 endometrial carcinomas (EC), 5 carcinosarcomas (MMMT), 8 uterine leiomyomas (ULMO), 7 uterine leiomyosarcomas (ULMS), 15 uterine tumor resembling ovarian sex cord tumors (UTROSCT), 17 low-grade endometrial stromal sarcomas (LGESS) and 9 high-grade endometrial stromal sarcomas (HGESS). Analysis of methylation data identified distinct methylation clusters, which correlated with established diagnostic categories of uterine neoplasms. MMMT clustered together with EC, while ULMO, ULMS and UTROSCT each formed distinct clusters. The LGESS cluster differed from that of HGESS, and within the branch of HGESS, we observed a notable subgrouping of YWHAE- and BCOR-rearranged tumors.Herein, we describe distinct DNA methylation signatures in uterine neoplasms and show that array-based DNA methylation analysis holds promise as an ancillary tool to further characterize uterine neoplasms, especially in cases which are diagnostically challenging by conventional techniques.
000148317 536__ $$0G:(DE-HGF)POF3-312$$a312 - Functional and structural genomics (POF3-312)$$cPOF3-312$$fPOF III$$x0
000148317 542__ $$2Crossref$$i2019-11-25$$uhttp://www.springer.com/tdm
000148317 542__ $$2Crossref$$i2019-11-25$$uhttp://www.springer.com/tdm
000148317 588__ $$aDataset connected to CrossRef, PubMed,
000148317 7001_ $$0P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aStichel, Damian$$b1
000148317 7001_ $$0P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc$$aSchrimpf, Daniel$$b2
000148317 7001_ $$aKriegsmann, Mark$$b3
000148317 7001_ $$aTessier-Cloutier, Basile$$b4
000148317 7001_ $$aTalhouk, Aline$$b5
000148317 7001_ $$aMcAlpine, Jessica N$$b6
000148317 7001_ $$aChang, Kenneth T E$$b7
000148317 7001_ $$0P:(DE-He78)a46a5b2a871859c8e2d63d2f8c666807$$aSturm, Dominik$$b8
000148317 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b9
000148317 7001_ $$aRomero-Pérez, Laura$$b10
000148317 7001_ $$aKirchner, Thomas$$b11
000148317 7001_ $$0P:(DE-He78)7a590ab95c6f7ba52880452da78ecd6c$$aGrünewald, Thomas G P$$b12
000148317 7001_ $$aBuslei, Rolf$$b13
000148317 7001_ $$aSinn, Hans-Peter$$b14
000148317 7001_ $$aMechtersheimer, Gunhild$$b15
000148317 7001_ $$aSchirmacher, Peter$$b16
000148317 7001_ $$aSchmidt, Dietmar$$b17
000148317 7001_ $$aLehr, Hans-Anton$$b18
000148317 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b19
000148317 7001_ $$aHuntsman, David G$$b20
000148317 7001_ $$aGilks, C Blake$$b21
000148317 7001_ $$aKommoss, Friedrich$$b22
000148317 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b23$$eLast author
000148317 7001_ $$00000-0001-8763-8864$$aKoelsche, Christian$$b24
000148317 77318 $$2Crossref$$3journal-article$$a10.1007/s00432-019-03093-w$$bSpringer Science and Business Media LLC$$d2019-11-25$$n1$$p97-104$$tJournal of Cancer Research and Clinical Oncology$$v146$$x0171-5216$$y2019
000148317 773__ $$0PERI:(DE-600)1459285-X$$a10.1007/s00432-019-03093-w$$n1$$p97-104$$tJournal of cancer research and clinical oncology$$v146$$x0171-5216$$y2020
000148317 909CO $$ooai:inrepo02.dkfz.de:148317$$pVDB
000148317 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000148317 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000148317 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a46a5b2a871859c8e2d63d2f8c666807$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000148317 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000148317 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7a590ab95c6f7ba52880452da78ecd6c$$aDeutsches Krebsforschungszentrum$$b12$$kDKFZ
000148317 9101_ $$0I:(DE-HGF)0$$6P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aExternal Institute$$b19$$kExtern
000148317 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$aDeutsches Krebsforschungszentrum$$b23$$kDKFZ
000148317 9131_ $$0G:(DE-HGF)POF3-312$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vFunctional and structural genomics$$x0
000148317 9141_ $$y2020
000148317 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000148317 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000148317 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000148317 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ CANCER RES CLIN : 2015
000148317 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000148317 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000148317 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000148317 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000148317 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000148317 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000148317 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000148317 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000148317 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000148317 9202_ $$0I:(DE-He78)B300-20160331$$kB300$$lKKE Neuropathologie$$x0
000148317 9201_ $$0I:(DE-He78)B300-20160331$$kB300$$lKKE Neuropathologie$$x0
000148317 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lB062 Pädiatrische Neuroonkologie$$x1
000148317 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x2
000148317 980__ $$ajournal
000148317 980__ $$aVDB
000148317 980__ $$aI:(DE-He78)B300-20160331
000148317 980__ $$aI:(DE-He78)B062-20160331
000148317 980__ $$aI:(DE-He78)HD01-20160331
000148317 980__ $$aUNRESTRICTED
000148317 999C5 $$1B Altrabulsi$$2Crossref$$9-- missing cx lookup --$$a10.1097/01.pas.0000171003.72352.9a$$p1316 -$$tAm J Surg Pathol$$uAltrabulsi B, Malpica A, Deavers MT, Bodurka DC, Broaddus R, Silva EG (2005) Undifferentiated carcinoma of the endometrium. Am J Surg Pathol 29(10):1316–1321$$v29$$y2005
000148317 999C5 $$1C Bodelon$$2Crossref$$9-- missing cx lookup --$$a10.1158/1078-0432.CCR-18-3720$$tClin Cancer Res$$uBodelon C, Killian JK, Sampson JN, Anderson WF, Matsuno R, Brinton LA, Wentzensen N (2019) Molecular classification of epithelial ovarian cancer based on methylation profiling: evidence for survival heterogeneity. Clin Cancer Res. https://doi.org/10.1158/1078-0432.CCR-18-3720$$y2019
000148317 999C5 $$1RA Brooks$$2Crossref$$9-- missing cx lookup --$$a10.3322/caac.21561$$p258 -$$tCA Cancer J Clin$$uBrooks RA, Fleming GF, Lastra RR, Lee NK, Moroney JW, Son CH, Veneris JL (2019) Current recommendations and recent progress in endometrial cancer. CA Cancer J Clin 69(4):258–279. https://doi.org/10.3322/caac.21561$$v69$$y2019
000148317 999C5 $$1D Capper$$2Crossref$$9-- missing cx lookup --$$a10.1038/nature26000$$p469 -$$tNature$$uCapper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D, Pfister SM (2018) DNA methylation-based classification of central nervous system tumours. Nature 555(7697):469–474. https://doi.org/10.1038/nature26000$$v555$$y2018
000148317 999C5 $$1AD Cherniack$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ccell.2017.02.010$$p411 -$$tCancer Cell$$uCherniack AD, Shen H, Walter V, Stewart C, Murray BA, Bowlby R, Levine DA (2017) integrated molecular characterization of uterine carcinosarcoma. Cancer Cell 31(3):411–423. https://doi.org/10.1016/j.ccell.2017.02.010$$v31$$y2017
000148317 999C5 $$1S Chiang$$2Crossref$$9-- missing cx lookup --$$a10.1038/modpathol.2017.42$$p1251 -$$tMod Pathol$$uChiang S, Lee CH, Stewart CJR, Oliva E, Hoang LN, Ali RH, Soslow RA (2017) BCOR is a robust diagnostic immunohistochemical marker of genetically diverse high-grade endometrial stromal sarcoma, including tumors exhibiting variant morphology. Mod Pathol 30(9):1251–1261. https://doi.org/10.1038/modpathol.2017.42$$v30$$y2017
000148317 999C5 $$1BC Dickson$$2Crossref$$9-- missing cx lookup --$$a10.1097/PAS.0000000000001153$$p178 -$$tAm J Surg Pathol$$uDickson BC, Childs TJ, Colgan TJ, Sung YS, Swanson D, Zhang L, Antonescu CR (2019) Uterine tumor resembling ovarian sex cord tumor: a distinct entity characterized by recurrent NCOA2/3 gene fusions. Am J Surg Pathol 43(2):178–186. https://doi.org/10.1097/PAS.0000000000001153$$v43$$y2019
000148317 999C5 $$1M Esteller$$2Crossref$$9-- missing cx lookup --$$a10.1038/nrg2005$$p286 -$$tNat Rev Genet$$uEsteller M (2007) Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 8(4):286–298. https://doi.org/10.1038/nrg2005$$v8$$y2007
000148317 999C5 $$1Z Fan$$2Crossref$$9-- missing cx lookup --$$a10.1038/ncb1913$$p1002 -$$tNat Cell Biol$$uFan Z, Yamaza T, Lee JS, Yu J, Wang S, Fan G, Wang CY (2009) BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol 11(8):1002–1009. https://doi.org/10.1038/ncb1913$$v11$$y2009
000148317 999C5 $$1AF Fernandez$$2Crossref$$9-- missing cx lookup --$$a10.1101/gr.119867.110$$p407 -$$tGenome Res$$uFernandez AF, Assenov Y, Martin-Subero JI, Balint B, Siebert R, Taniguchi H, Esteller M (2012) A DNA methylation fingerprint of 1628 human samples. Genome Res 22(2):407–419. https://doi.org/10.1101/gr.119867.110$$v22$$y2012
000148317 999C5 $$1EA Goebel$$2Crossref$$9-- missing cx lookup --$$a10.1097/pas.0000000000001348$$tAm J Surg Pathol$$uGoebel EA, Hernandez Bonilla S, Dong F, Dickson BC, Hoang LN, Hardisson D, Kolin DL (2019) Uterine tumor resembling ovarian sex cord tumor (UTROSCT): a morphologic and molecular study of 26 cases confirms recurrent NCOA1-3 rearrangement. Am J Surg Pathol. https://doi.org/10.1097/pas.0000000000001348(Epub ahead of print)$$y2019
000148317 999C5 $$1G Gremel$$2Crossref$$9-- missing cx lookup --$$a10.1002/ijc.29141$$p1608 -$$tInt J Cancer$$uGremel G, Liew M, Hamzei F, Hardell E, Selling J, Ghaderi M, Carlson JW (2015) A prognosis based classification of undifferentiated uterine sarcomas: identification of mitotic index, hormone receptors and YWHAE-FAM22 translocation status as predictors of survival. Int J Cancer 136(7):1608–1618. https://doi.org/10.1002/ijc.29141$$v136$$y2015
000148317 999C5 $$1KG Griewank$$2Crossref$$9-- missing cx lookup --$$a10.1038/modpathol.2017.146$$p418 -$$tMod Pathol$$uGriewank KG, Wiesner T, Murali R, Pischler C, Muller H, Koelsche C, Sucker A (2018) Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles. Mod Pathol 31(3):418–428. https://doi.org/10.1038/modpathol.2017.146$$v31$$y2018
000148317 999C5 $$1LN Hoang$$2Crossref$$9-- missing cx lookup --$$a10.1097/PAS.0000000000000721$$p12 -$$tAm J Surg Pathol$$uHoang LN, Aneja A, Conlon N, DeLair D, Middha S, Benayed R, Chiang S (2017) Novel high-grade endometrial stromal sarcoma—a morphologic mimicker of myxoid leiomyosarcoma. Am J Surg Pathol 41(1):12–24$$v41$$y2017
000148317 999C5 $$1L Hoang$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.pathol.2017.11.086$$p162 -$$tPathology$$uHoang L, Chiang S, Lee CH (2018) Endometrial stromal sarcomas and related neoplasms: new developments and diagnostic considerations. Pathology 50(2):162–177. https://doi.org/10.1016/j.pathol.2017.11.086$$v50$$y2018
000148317 999C5 $$1V Hovestadt$$2Crossref$$9-- missing cx lookup --$$a10.1038/nature13268$$p537 -$$tNature$$uHovestadt V, Jones DT, Picelli S, Wang W, Kool M, Northcott PA, Lichter P (2014) Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature 510(7506):537–541. https://doi.org/10.1038/nature13268$$v510$$y2014
000148317 999C5 $$1C Kandoth$$2Crossref$$9-- missing cx lookup --$$a10.1038/nature12113$$p67 -$$tNature$$uKandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Levine DA (2013) Integrated genomic characterization of endometrial carcinoma. Nature 497(7447):67–73. https://doi.org/10.1038/nature12113$$v497$$y2013
000148317 999C5 $$1C Koelsche$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41379-018-0045-3$$p1246 -$$tMod Pathol$$uKoelsche C, Hartmann W, Schrimpf D, Stichel D, Jabar S, Ranft A, von Deimling A (2018) Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information. Mod Pathol 31(8):1246–1256. https://doi.org/10.1038/s41379-018-0045-3$$v31$$y2018
000148317 999C5 $$1C Koelsche$$2Crossref$$9-- missing cx lookup --$$a10.1007/s00432-019-02895-2$$p1273 -$$tJ Cancer Res Clin Oncol$$uKoelsche C, Kriegsmann M, Kommoss FKF, Stichel D, Kriegsmann K, Vokuhl C, von Deimling A (2019) DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma. J Cancer Res Clin Oncol 145(5):1273–1281. https://doi.org/10.1007/s00432-019-02895-2$$v145$$y2019
000148317 999C5 $$1RJ Kurman$$2Crossref$$tWHO classification of tumours of female reproductive organs$$uKurman RJ, Carcangiu ML, Herrington CS, Young RH (2014) WHO classification of tumours of female reproductive organs. IARC, Lyon, p 6$$y2014
000148317 999C5 $$1N Lewis$$2Crossref$$9-- missing cx lookup --$$a10.1038/modpathol.2017.162$$p674 -$$tMod Pathol$$uLewis N, Soslow RA, Delair DF, Park KJ, Murali R, Hollmann TJ, Chiang S (2018) ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity. Mod Pathol 31(4):674–684. https://doi.org/10.1038/modpathol.2017.162$$v31$$y2018
000148317 999C5 $$1A Mariño-Enriquez$$2Crossref$$9-- missing cx lookup --$$a10.1097/PAS.0000000000000993$$p335 -$$tAm J Surg Pathol$$uMariño-Enriquez A, Lauria A, Przybyl J, Ng L, Kowalewska M, Debiec-Rychter M, Fletcher J (2018) BCOR internal tandem duplication in high-grade uterine sarcomas. Am J Surg Pathol 42(3):335–341$$v42$$y2018
000148317 999C5 $$1WG McCluggage$$2Crossref$$9-- missing cx lookup --$$a10.1136/ijgc-00009577-200211000-00001$$p687 -$$tInt J Gynecol Cancer$$uMcCluggage WG (2002) Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas. Int J Gynecol Cancer 12(6):687–690$$v12$$y2002
000148317 999C5 $$1KW Pajtler$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ccell.2015.04.002$$p728 -$$tCancer Cell$$uPajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Johann PJCC (2015) Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups. Cancer Cell 27(5):728–743. https://doi.org/10.1016/j.ccell.2015.04.002$$v27$$y2015
000148317 999C5 $$1I Panagopoulos$$2Crossref$$9-- missing cx lookup --$$a10.1002/gcc.22057$$p610 -$$tGenes Chromosom Cancer$$uPanagopoulos I, Thorsen J, Gorunova L, Haugom L, Bjerkehagen B, Davidson B, Micci F (2013) Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation. Genes Chromosom Cancer 52(7):610–618. https://doi.org/10.1002/gcc.22057$$v52$$y2013
000148317 999C5 $$1M Rohrich$$2Crossref$$9-- missing cx lookup --$$a10.1007/s00401-016-1540-6$$p877 -$$tActa Neuropathol$$uRohrich M, Koelsche C, Schrimpf D, Capper D, Sahm F, Kratz A, Reuss DE (2016) Methylation-based classification of benign and malignant peripheral nerve sheath tumors. Acta Neuropathol 131(6):877–887. https://doi.org/10.1007/s00401-016-1540-6$$v131$$y2016
000148317 999C5 $$1J Sandoval$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.gde.2012.02.008$$p50 -$$tCurr Opin Genet Dev$$uSandoval J, Esteller M (2012) Cancer epigenomics: beyond genomics. Curr Opin Genet Dev 22(1):50–55. https://doi.org/10.1016/j.gde.2012.02.008$$v22$$y2012
000148317 999C5 $$1M Seki$$2Crossref$$9-- missing cx lookup --$$a10.1038/ncomms8557$$p7558 -$$tNat Commun$$uSeki M, Nishimura R, Yoshida K, Shimamura T, Shiraishi Y, Sato Y, Hoshino N (2015) Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma. Nat Commun 6:7558. https://doi.org/10.1038/ncomms8557$$v6$$y2015
000148317 999C5 $$1H Shen$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2013.03.008$$p38 -$$tCell$$uShen H, Laird PW (2013) Interplay between the cancer genome and epigenome. Cell 153(1):38–55. https://doi.org/10.1016/j.cell.2013.03.008$$v153$$y2013
000148317 999C5 $$1RL Siegel$$2Crossref$$9-- missing cx lookup --$$a10.3322/caac.21551$$p7 -$$tCA Cancer J Clin$$uSiegel RL, Miller KD, Jemal A (2019) Cancer statistics. CA Cancer J Clin 69(1):7–34. https://doi.org/10.3322/caac.21551$$v69$$y2019
000148317 999C5 $$1PN Staats$$2Crossref$$9-- missing cx lookup --$$a10.1097/PAS.0b013e3181a7b9cf$$p1206 -$$tAm J Surg Pathol$$uStaats PN, Garcia JJ, Dias-Santagata DC, Kuhlmann G, Stubbs H, McCluggage WG, Oliva E (2009) Uterine tumors resembling ovarian sex cord tumors (UTROSCT) lack the JAZF1–JJAZ1 translocation frequently seen in endometrial stromal tumors. Am J Surg Pathol 33(8):1206–1212. https://doi.org/10.1097/PAS.0b013e3181a7b9cf$$v33$$y2009
000148317 999C5 $$1D Sturm$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2016.01.015$$p1060 -$$tCell$$uSturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Kool M (2016) New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell 164(5):1060–1072. https://doi.org/10.1016/j.cell.2016.01.015$$v164$$y2016
000148317 999C5 $$1A Talhouk$$2Crossref$$9-- missing cx lookup --$$a10.1038/bjc.2015.190$$p299 -$$tBr J Cancer$$uTalhouk A, McConechy MK, Leung S, Li-Chang HH, Kwon JS, Melnyk N, McAlpine JN (2015) A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer 113(2):299–310. https://doi.org/10.1038/bjc.2015.190$$v113$$y2015
000148317 999C5 $$1L van der Maaten$$2Crossref$$uvan der Maaten L, Hinton G (2008) Visualizing Data using t-SNE. J Mach Learn Res 9:2579–2605$$y2008