%0 Journal Article
%A Weigl, Korbinian
%A Hsu, Li
%A Knebel, Phillip
%A Hoffmeister, Michael
%A Timofeeva, Maria
%A Farrington, Susan
%A Dunlop, Malcolm
%A Brenner, Hermann
%T Head-to-Head Comparison of Family History of Colorectal Cancer and a Genetic Risk Score for Colorectal Cancer Risk Stratification.
%J Clinical and translational gastroenterology
%V 10
%N 12
%@ 2155-384X
%C London
%I Nature Publ. Group
%M DKFZ-2019-02918
%P e00106
%D 2019
%Z EA:C070LA:C0702019 Dec;10(12):e00106
%X Family history (FH) is associated with increased risk of colorectal cancer (CRC). We aimed to examine the potential for CRC risk stratification by known common genetic variants beyond FH in a large population-based case-control study from Germany.Four thousand four hundred forty-seven cases and 3,480 controls recruited in 2003-2016 were included for whom comprehensive interview, medical, and genomic data were available. Associations with CRC risk were estimated from multiple logistic regression models for FH and a genetic risk score (GRS) based on 90 previously identified risk variants.CRC in a first-degree relative was associated with a 1.71-fold (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31800541
%R 10.14309/ctg.0000000000000106
%U https://inrepo02.dkfz.de/record/148362