TY  - JOUR
AU  - Weigl, Korbinian
AU  - Hsu, Li
AU  - Knebel, Phillip
AU  - Hoffmeister, Michael
AU  - Timofeeva, Maria
AU  - Farrington, Susan
AU  - Dunlop, Malcolm
AU  - Brenner, Hermann
TI  - Head-to-Head Comparison of Family History of Colorectal Cancer and a Genetic Risk Score for Colorectal Cancer Risk Stratification.
JO  - Clinical and translational gastroenterology
VL  - 10
IS  - 12
SN  - 2155-384X
CY  - London
PB  - Nature Publ. Group
M1  - DKFZ-2019-02918
SP  - e00106
PY  - 2019
N1  - EA:C070LA:C0702019 Dec;10(12):e00106
AB  - Family history (FH) is associated with increased risk of colorectal cancer (CRC). We aimed to examine the potential for CRC risk stratification by known common genetic variants beyond FH in a large population-based case-control study from Germany.Four thousand four hundred forty-seven cases and 3,480 controls recruited in 2003-2016 were included for whom comprehensive interview, medical, and genomic data were available. Associations with CRC risk were estimated from multiple logistic regression models for FH and a genetic risk score (GRS) based on 90 previously identified risk variants.CRC in a first-degree relative was associated with a 1.71-fold (95
LB  - PUB:(DE-HGF)16
C6  - pmid:31800541
DO  - DOI:10.14309/ctg.0000000000000106
UR  - https://inrepo02.dkfz.de/record/148362
ER  -