%0 Journal Article
%A Mock, Andreas
%A Heilig, Christoph E
%A Kreutzfeldt, Simon
%A Huebschmann, Daniel
%A Heining, Christoph
%A Schröck, Evelin
%A Brors, Benedikt
%A Stenzinger, Albrecht
%A Jäger, Dirk
%A Schlenk, Richard
%A Glimm, Hanno
%A Fröhling, Stefan
%A Horak, Peter
%A Apostolidis, Leonidas
%A Augustin, Marinela
%A Aust, Daniela
%A Bhatti, Irfan Ahmed
%A Bloehdorn, Johannes
%A Brendel, Cornelia
%A Britschgi, Christian
%A Braess, Jan
%A Burdach, Stefan
%A Busch, Elena
%A Casuscelli, Jozefina
%A Desuki, Alexander
%A Deutsch, Thomas
%A Dietrich, Mareike
%A Ehmer, Ursula
%A Ettrich, Thomas J
%A Falkenhorst, Johanna
%A Fehm, Tanja
%A Flörcken, Anne
%A Forschner, Andrea
%A Fuxius, Stefan
%A Gonzales-Carmona, Maria
%A Griesinger, Frank
%A Grill, Sabine
%A Gröschel, Stefan
%A Haag, Georg Martin
%A Haag, Ulrich
%A Halama, Niels
%A Hebart, Holger
%A Heidger, Nina
%A Hermes, Barbara
%A Hess, Georg
%A Hettmer, Simone
%A Hoechstetter, Manuela
%A Hoffmann, Martin
%A Hüttner, Felix J
%A Illert, Anna L
%A Jenzer, Maximilian
%A Kasper, Bernd
%A Kasper-Virchow, Stefan
%A Kindler, Thomas
%A Koscielniak, Ewa
%A Krönke, Jan
%A Kühn, Michael
%A Kunzmann, Volker
%A Lang, Alois
%A Leichsenring, Jonas
%A Livingstone, Elisabeth
%A Liotta, Lucia
%A Luley, Kim
%A Mack, Elisabeth
%A Martens, Uwe M
%A Metzeler, Klaus
%A Middeke, Jan Moritz
%A Möhrmann, Lino
%A Jayarama-Naidu, Roopa
%A Pape, Ulrich-Frank
%A Perkhofer, Lukas
%A Pfeufer, Arne
%A Pixberg, Constantin
%A Quante, Michael
%A Rendenbach, Bernhard
%A Rieke, Damian
%A Rothermundt, Christian
%A Sagerer, Andre Norbert
%A Salzmann, Martin
%A Saur, Dieter
%A Schilling, Bastian
%A Schleicher, Jan
%A Schlenska-Lange, Anke
%A Schmidt, Thomas
%A Schmitz, Sophia
%A Schölch, Sebastian
%A Shah, Rajiv
%A Shoumariyeh, Khalid
%A Siebenhüner, Alexander
%A Singh, Martin
%A Siveke, Jens
%A Springfeld, Christoph
%A Starke, Helen
%A Strobel, Sophia
%A Teleanu, Veronica
%A Thon, Niklas
%A Wagner, Sebastian
%A Walle, Thomas
%A Westphalen, Benedikt
%A Whitlock, Bettina
%A Winkler, Eva
%A Wirsik, Naita Maren
%A Woydack, Lena
%A Bois, Angelika Zabel-du
%A Zschäbitz, Stefanie
%T Community-driven development of a modified progression-free survival ratio for precision oncology.
%J ESMO open
%V 4
%N 6
%@ 2059-7029
%C London
%I BMJ
%M DKFZ-2019-02922
%P e000583
%D 2019
%X Measuring the success of molecularly guided therapies is a major challenge in precision oncology trials. A commonly used endpoint is an intra-patient progression-free survival (PFS) ratio, defined as the PFS interval associated with molecularly guided therapy (PFS2) divided by the PFS interval associated with the last prior systemic therapy (PFS1), above 1.3 or, in some studies, above 1.33 or 1.5.To investigate if the concept of PFS ratios is in agreement with actual response evaluations by physicians, we conducted a survey among members of the MASTER (Molecularly Aided Stratification for Tumor Eradication Research) Programme of the German Cancer Consortium who were asked to classify the success of molecularly guided therapies in 194 patients enrolled in the MOSCATO 01 trial based on PFS1 and PFS2 times.A comparison of classification profiles revealed three distinct clusters of PFS benefit assessments. Only 29
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31798980
%2 pmc:PMC6863673
%R 10.1136/esmoopen-2019-000583
%U https://inrepo02.dkfz.de/record/148366